LONG-TERM TREATMENT OF PARKINSONISM WITH BROMOCRIPTINE

Donald B. Calne, Adrian C. Williams, Andreas Neophytides, Charles Plotkin, John G. Nutt, Paul F. Teychenne

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

92 patients with parkinsonism have been treated with bromocriptine for up to 30 months. 48 continue to receive bromocriptine with benefit; of these, 35 take bromocriptine (mean dose 53 mg daily) in combination with levodopa and 13 take bromocriptine (mean dose 45 mg daily) without levodopa. In those who were originally on levodopa, addition of bromocriptine allowed a mean 41% reduction in the dose of levodopa; the largest group of patients to benefit from bromocriptine entered the study because of excessive dyskinesia or "on-off" phenomena induced by levodopa. In 40 patients bromocriptine was stopped because of adverse reactions, absence of therapeutic response, or non-compliance with the protocol. The main problems were psychiatric disturbance (8 patients) and erythromelalgia (7 patients); these effects tended to occur late (mean 6 months and 10 months, respectively) and with high dosage (mean 66 mg and 115 mg daily). Other fre quent adverse effects were dizziness and nausea; these began considerably earlier (at 2 months and 1 month) and with much lower dosage (31 mg and 12 mg daily). 4 patients died, for reasons apparently unrelated to therapy.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalThe Lancet
Volume311
Issue number8067
DOIs
StatePublished - Apr 8 1978

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'LONG-TERM TREATMENT OF PARKINSONISM WITH BROMOCRIPTINE'. Together they form a unique fingerprint.

  • Cite this

    Calne, D. B., Williams, A. C., Neophytides, A., Plotkin, C., Nutt, J. G., & Teychenne, P. F. (1978). LONG-TERM TREATMENT OF PARKINSONISM WITH BROMOCRIPTINE. The Lancet, 311(8067), 735-738. https://doi.org/10.1016/S0140-6736(78)90856-5