Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study

Adel Kardosh, Daphne Y. Lichtensztajn, Matthew A. Gubens, Pamela L. Kunz, George A. Fisher, Christina A. Clarke

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pancreatic cancer continues to carry a poor prognosis with survival rates that have had minimal improvement over the past 4 decades. We report a population-based, comprehensive analysis of long-term survivors of pancreatic adenocarcinoma diagnosed in the diverse population of California. Methods Data from the California Cancer Registry were used to evaluate long-term survival. A total of 70,442 patients diagnosed with pancreatic adenocarcinoma between 1988 and 2009 were identified. Logistic regression was used to identify factors associated with achieving 5-year survival. Results The overall 5-year survival was 2.5%, with minimal incremental improvements throughout the 3 decades. Age, stage, degree of differentiation, and surgical resection were associated with 5-year survival. Furthermore, younger age and receiving care at a National Cancer Institute-designated cancer center were similarly correlated with 5-year survival regardless of surgical intervention. In addition, we identified stage, differentiation, and adjuvant chemotherapy as significant factors for long-term survival in surgically resected patients. In the unresectable patients, Asian/Pacific islanders and Hispanics were significantly more likely to reach the 5-year milestone than non-Hispanic whites. Conclusions Although pancreatic cancer mortality remains high, our study highlights baseline characteristics, treatment, biological factors, and ethnicity that are associated with long-term survival. These findings may serve as a springboard for further investigation.

Original languageEnglish (US)
Pages (from-to)958-966
Number of pages9
JournalPancreas
Volume47
Issue number8
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Survivors
Survival
Population
Adenocarcinoma
National Cancer Institute (U.S.)
Biological Factors
Adjuvant Chemotherapy
Hispanic Americans
Registries
Neoplasms
Survival Rate
Logistic Models
Mortality

Keywords

  • chemotherapy
  • differentiation
  • long-term survival
  • pancreatic adenocarcinoma
  • race/ethnicity
  • surgical resection

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Kardosh, A., Lichtensztajn, D. Y., Gubens, M. A., Kunz, P. L., Fisher, G. A., & Clarke, C. A. (2018). Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study. Pancreas, 47(8), 958-966. https://doi.org/10.1097/MPA.0000000000001133

Long-Term Survivors of Pancreatic Cancer : A California Population-Based Study. / Kardosh, Adel; Lichtensztajn, Daphne Y.; Gubens, Matthew A.; Kunz, Pamela L.; Fisher, George A.; Clarke, Christina A.

In: Pancreas, Vol. 47, No. 8, 01.09.2018, p. 958-966.

Research output: Contribution to journalArticle

Kardosh, A, Lichtensztajn, DY, Gubens, MA, Kunz, PL, Fisher, GA & Clarke, CA 2018, 'Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study', Pancreas, vol. 47, no. 8, pp. 958-966. https://doi.org/10.1097/MPA.0000000000001133
Kardosh A, Lichtensztajn DY, Gubens MA, Kunz PL, Fisher GA, Clarke CA. Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study. Pancreas. 2018 Sep 1;47(8):958-966. https://doi.org/10.1097/MPA.0000000000001133
Kardosh, Adel ; Lichtensztajn, Daphne Y. ; Gubens, Matthew A. ; Kunz, Pamela L. ; Fisher, George A. ; Clarke, Christina A. / Long-Term Survivors of Pancreatic Cancer : A California Population-Based Study. In: Pancreas. 2018 ; Vol. 47, No. 8. pp. 958-966.
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