Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse

Jozsef Vigh, Geng Lin Li, Court Hull, Henrique Von Gersdorff

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABAA IPSCs and a much slower and more sustained GABAC feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

Original languageEnglish (US)
Pages (from-to)469-482
Number of pages14
JournalNeuron
Volume46
Issue number3
DOIs
Publication statusPublished - May 5 2005

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this