Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse

Jozsef Vigh; Geng Lin Li; Court Hull; Henrique Von Gersdorff

doi:10.1016/j.neuron.2005.03.027

Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse

Jozsef Vigh, Geng Lin Li, Court Hull, Henrique Von Gersdorff

Vollum Institute

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABA_A IPSCs and a much slower and more sustained GABA_C feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

Original language	English (US)
Pages (from-to)	469-482
Number of pages	14
Journal	Neuron
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2005.03.027
State	Published - May 5 2005

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2005.03.027

Cite this

@article{abe5a879f28844388572259e67be88fd,

title = "Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse",

abstract = "The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABAA IPSCs and a much slower and more sustained GABAC feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.",

author = "Jozsef Vigh and Li, {Geng Lin} and Court Hull and {Von Gersdorff}, Henrique",

note = "Funding Information: We thank Dr. Paul Witkovsky, New York University Medical Center, and Dr. Ko Matsui, Vollum Institute, for critically reading and commenting on the manuscript. This research was supported by HFSP and NIH-NEI grants.",

year = "2005",

month = may,

day = "5",

doi = "10.1016/j.neuron.2005.03.027",

language = "English (US)",

volume = "46",

pages = "469--482",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse

AU - Vigh, Jozsef

AU - Li, Geng Lin

AU - Hull, Court

AU - Von Gersdorff, Henrique

N1 - Funding Information: We thank Dr. Paul Witkovsky, New York University Medical Center, and Dr. Ko Matsui, Vollum Institute, for critically reading and commenting on the manuscript. This research was supported by HFSP and NIH-NEI grants.

PY - 2005/5/5

Y1 - 2005/5/5

N2 - The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABAA IPSCs and a much slower and more sustained GABAC feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

AB - The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABAA IPSCs and a much slower and more sustained GABAC feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

UR - http://www.scopus.com/inward/record.url?scp=18144384756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18144384756&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2005.03.027

DO - 10.1016/j.neuron.2005.03.027

M3 - Article

C2 - 15882646

AN - SCOPUS:18144384756

SN - 0896-6273

VL - 46

SP - 469

EP - 482

JO - Neuron

JF - Neuron

IS - 3

ER -

Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this