Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients

J. L. Gajewski, S. Nimer, R. M. Saliba, M. Thomas, D. Przepiorka, S. Giralt, K. Von Besien, R. Mehra, B. Andersson, K. W. Chan, C. Ippoliti, D. Warkinten, S. Feigs, M. Territo, G. Schiller, J. Lebkowski, A. M. Moseley, K. Lloyd, M. Von Hoeff, T. OkarmaR. Champlin

    Research output: Contribution to journalArticle

    Abstract

    Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9%; of Grade 3-4 GvHD, 11 ± 6%. The 4-year cumulative risk of relapse was 18 ± 8% and actuarial survival was 44 ± 9%. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.

    Original languageEnglish (US)
    Pages (from-to)401-407
    Number of pages7
    JournalCytotherapy
    Volume1
    Issue number5
    DOIs
    StatePublished - 1999

    Keywords

    • Bone marrow
    • T-cell depletion
    • Unrelated

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Oncology
    • Genetics(clinical)
    • Cell Biology
    • Cancer Research
    • Transplantation

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    Gajewski, J. L., Nimer, S., Saliba, R. M., Thomas, M., Przepiorka, D., Giralt, S., Von Besien, K., Mehra, R., Andersson, B., Chan, K. W., Ippoliti, C., Warkinten, D., Feigs, S., Territo, M., Schiller, G., Lebkowski, J., Moseley, A. M., Lloyd, K., Von Hoeff, M., ... Champlin, R. (1999). Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients. Cytotherapy, 1(5), 401-407. https://doi.org/10.1080/0032472031000141284