Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients

J. L. Gajewski, S. Nimer, R. M. Saliba, M. Thomas, D. Przepiorka, S. Giralt, K. Von Besien, R. Mehra, B. Andersson, K. W. Chan, C. Ippoliti, D. Warkinten, S. Feigs, M. Territo, G. Schiller, J. Lebkowski, A. M. Moseley, K. Lloyd, M. Von Hoeff, T. OkarmaR. Champlin

Research output: Contribution to journalArticle

Abstract

Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9%; of Grade 3-4 GvHD, 11 ± 6%. The 4-year cumulative risk of relapse was 18 ± 8% and actuarial survival was 44 ± 9%. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.

Original languageEnglish (US)
Pages (from-to)401-407
Number of pages7
JournalCytotherapy
Volume1
Issue number5
StatePublished - 1999
Externally publishedYes

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CD8-Positive T-Lymphocytes
Unrelated Donors
T-Lymphocytes
Transplants
Antigens
Recurrence
Tissue Donors
HLA-A Antigens
HLA-B Antigens
Survival
HLA-DR Antigens
Bone Marrow

Keywords

  • Bone marrow
  • T-cell depletion
  • Unrelated

ASJC Scopus subject areas

  • Immunology

Cite this

Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients. / Gajewski, J. L.; Nimer, S.; Saliba, R. M.; Thomas, M.; Przepiorka, D.; Giralt, S.; Von Besien, K.; Mehra, R.; Andersson, B.; Chan, K. W.; Ippoliti, C.; Warkinten, D.; Feigs, S.; Territo, M.; Schiller, G.; Lebkowski, J.; Moseley, A. M.; Lloyd, K.; Von Hoeff, M.; Okarma, T.; Champlin, R.

In: Cytotherapy, Vol. 1, No. 5, 1999, p. 401-407.

Research output: Contribution to journalArticle

Gajewski, JL, Nimer, S, Saliba, RM, Thomas, M, Przepiorka, D, Giralt, S, Von Besien, K, Mehra, R, Andersson, B, Chan, KW, Ippoliti, C, Warkinten, D, Feigs, S, Territo, M, Schiller, G, Lebkowski, J, Moseley, AM, Lloyd, K, Von Hoeff, M, Okarma, T & Champlin, R 1999, 'Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients', Cytotherapy, vol. 1, no. 5, pp. 401-407.
Gajewski, J. L. ; Nimer, S. ; Saliba, R. M. ; Thomas, M. ; Przepiorka, D. ; Giralt, S. ; Von Besien, K. ; Mehra, R. ; Andersson, B. ; Chan, K. W. ; Ippoliti, C. ; Warkinten, D. ; Feigs, S. ; Territo, M. ; Schiller, G. ; Lebkowski, J. ; Moseley, A. M. ; Lloyd, K. ; Von Hoeff, M. ; Okarma, T. ; Champlin, R. / Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients. In: Cytotherapy. 1999 ; Vol. 1, No. 5. pp. 401-407.
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title = "Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients",
abstract = "Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94{\%}) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9{\%}; of Grade 3-4 GvHD, 11 ± 6{\%}. The 4-year cumulative risk of relapse was 18 ± 8{\%} and actuarial survival was 44 ± 9{\%}. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.",
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author = "Gajewski, {J. L.} and S. Nimer and Saliba, {R. M.} and M. Thomas and D. Przepiorka and S. Giralt and {Von Besien}, K. and R. Mehra and B. Andersson and Chan, {K. W.} and C. Ippoliti and D. Warkinten and S. Feigs and M. Territo and G. Schiller and J. Lebkowski and Moseley, {A. M.} and K. Lloyd and {Von Hoeff}, M. and T. Okarma and R. Champlin",
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T1 - Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients

AU - Gajewski, J. L.

AU - Nimer, S.

AU - Saliba, R. M.

AU - Thomas, M.

AU - Przepiorka, D.

AU - Giralt, S.

AU - Von Besien, K.

AU - Mehra, R.

AU - Andersson, B.

AU - Chan, K. W.

AU - Ippoliti, C.

AU - Warkinten, D.

AU - Feigs, S.

AU - Territo, M.

AU - Schiller, G.

AU - Lebkowski, J.

AU - Moseley, A. M.

AU - Lloyd, K.

AU - Von Hoeff, M.

AU - Okarma, T.

AU - Champlin, R.

PY - 1999

Y1 - 1999

N2 - Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9%; of Grade 3-4 GvHD, 11 ± 6%. The 4-year cumulative risk of relapse was 18 ± 8% and actuarial survival was 44 ± 9%. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.

AB - Background: Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. While T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD -without compromising outcomes. Method: In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. Results: 30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 ± 9%; of Grade 3-4 GvHD, 11 ± 6%. The 4-year cumulative risk of relapse was 18 ± 8% and actuarial survival was 44 ± 9%. Discussion :Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.

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KW - T-cell depletion

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