Long-term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency

K. F. Wilson, P. J. Fielder, J. Guevara-Aguirre, P. Cohen, O. Vasconez, V. Martinez, A. Martinez, A. L. Rosenbloom, R. G. Rosenfeld

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Objective. The aim of this investigation was to study the effect of relatively high dose IGF-I therapy given for several months, on serum levels of IGF-I, IGF-II and IGFBP-3, and on IGF-I pharmacokinetics in patients with growth hormone insensitivity due to GH receptor dysfunction. Design and patients. Two adolescent subjects from Ecuador were treated with recombinant IGF-I at a dosage of 120 μg/kg s.c. twice daily, in combination with a GnRH analogue for 8 months. Measurements. Serum was sampled at baseline and at 3-8 months, for determination of IGF-I, IGF-II and IGFBP-3 by radioimmunoassay, and for evaluation of IGFBPs and IGFBP-3 protease activity by Western ligand blot and protease assay, respectively. Results. Peak serum IGF-I levels ranged from 272 to 492 μg/l. Mean serum IGF-II levels were decreased concurrently with the increase in IGF-I. Serum IGFBP-3 levels failed to rise with prolonged IGF-I treatment. There was no apparent change in the half-life of IGF-I during the treatment period. Conclusions. IGF administration does not increase serum levels of IGFBP-3 or significantly alter IGF-I pharmacokinetics.

Original languageEnglish (US)
Pages (from-to)399-407
Number of pages9
JournalClinical Endocrinology
Volume42
Issue number4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Wilson, K. F., Fielder, P. J., Guevara-Aguirre, J., Cohen, P., Vasconez, O., Martinez, V., Martinez, A., Rosenbloom, A. L., & Rosenfeld, R. G. (1995). Long-term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency. Clinical Endocrinology, 42(4), 399-407. https://doi.org/10.1111/j.1365-2265.1995.tb02649.x