Long-term effects of differential early rearing in rhesus macaques

Behavioral reactivity in adulthood

Christopher A. Corcoran, Peter J. Pierre, Tyler Haddad, Christina Bice, Stephen J. Suomi, Kathleen (Kathy) Grant, David P. Friedman, Allyson J. Bennett

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    Adverse early experiences are associated with a range of deleterious health outcomes in humans, including higher risk for affective disorders. Studies using a long-standing model of nonhuman primate model of early adversity have demonstrated that nursery-reared (NR) monkeys exhibit alterations in multiple aspects of biobehavioral development; however, few studies have evaluated the persistence of socioaffective behavioral changes through adulthood. We evaluated the effects of early rearing experience on adult animals' response to a well-validated assessment of anxiety-like behavior, the human intruder paradigm (HIP). We tested 22 rhesus monkeys who were either nursery-reared (NR) or reared with their mothers (mother-reared; MR). NR monkeys were inhibited in their behavior compared to MR monkeys, with reduced locomotion and exploratory behaviors. NR animals showed a marginal increase in freezing. Together these findings demonstrate that the consequences of differential infant rearing experience on socioaffective behavior persist into adulthood, with evidence of greater inhibition in NR monkeys.

    Original languageEnglish (US)
    Pages (from-to)546-555
    Number of pages10
    JournalDevelopmental Psychobiology
    Volume54
    Issue number5
    DOIs
    StatePublished - Jul 2012

    Fingerprint

    Nurseries
    Macaca mulatta
    Haplorhini
    Mothers
    Exploratory Behavior
    Locomotion
    Mood Disorders
    Primates
    Freezing
    Anxiety
    Health

    Keywords

    • Adult
    • Affective behavior
    • Early experience
    • Human intruder
    • Lifespan
    • Rhesus monkey

    ASJC Scopus subject areas

    • Developmental Biology
    • Behavioral Neuroscience
    • Developmental Neuroscience
    • Developmental and Educational Psychology

    Cite this

    Long-term effects of differential early rearing in rhesus macaques : Behavioral reactivity in adulthood. / Corcoran, Christopher A.; Pierre, Peter J.; Haddad, Tyler; Bice, Christina; Suomi, Stephen J.; Grant, Kathleen (Kathy); Friedman, David P.; Bennett, Allyson J.

    In: Developmental Psychobiology, Vol. 54, No. 5, 07.2012, p. 546-555.

    Research output: Contribution to journalArticle

    Corcoran, CA, Pierre, PJ, Haddad, T, Bice, C, Suomi, SJ, Grant, KK, Friedman, DP & Bennett, AJ 2012, 'Long-term effects of differential early rearing in rhesus macaques: Behavioral reactivity in adulthood', Developmental Psychobiology, vol. 54, no. 5, pp. 546-555. https://doi.org/10.1002/dev.20613
    Corcoran, Christopher A. ; Pierre, Peter J. ; Haddad, Tyler ; Bice, Christina ; Suomi, Stephen J. ; Grant, Kathleen (Kathy) ; Friedman, David P. ; Bennett, Allyson J. / Long-term effects of differential early rearing in rhesus macaques : Behavioral reactivity in adulthood. In: Developmental Psychobiology. 2012 ; Vol. 54, No. 5. pp. 546-555.
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