Long-term effectiveness of weight-loss interventions in adults with pre-diabetes

A review

Susan L. Norris, Xuanping Zhang, Alison Avenell, Edward Gregg, Barbara Bowman, Christopher H. Schmid, Joseph Lau

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

To assess the effectiveness of weight-loss and weight-control interventions for adults with pre-diabetes (impaired fasting glucose and impaired glucose tolerance), an important risk factor for the development of type 2 diabetes. Computerized searches were conducted of multiple electronic bibliographic databases up to August 2003. Randomized controlled trials in any language were selected that examined weight-loss or weight-control strategies using at least one dietary, physical activity, or behavioral intervention, and with a follow-up interval of ≥12 months. Effects were combined using a random effects model. Studies were identified, with a total of 5168 participants. Follow-up ranged from 1 to 10 years. Quantitative synthesis was limited by the heterogeneity of populations, settings, and interventions, and by the small number of studies that examined outcomes other than weight. Overall, compared to usual care, four studies with a follow-up of 1 year reduced weight by 2.8 kg (95% confidence interval [CI]=1.04.7) (3.3% of baseline body weight) and decreased body mass index by 1.4 kg/m 2 (CI=0.52.3). Weight loss at 2 years was 2.7 kg (CI=1.93.4) (two studies). Modest improvements were noted in the few studies that examined glycemic control, blood pressure, and lipid concentrations (p >0.05). The incidence of diabetes was significantly lower in the intervention groups versus the controls in three of five studies examining this outcome at 3 to 6 years follow-up. Overall, weight-loss strategies using dietary, physical activity, or behavioral interventions produced significant improvements in weight among persons with pre-diabetes, and a significant decrease in diabetes incidence. Further work is needed on the long-term effects of these interventions on morbidity and mortality and on how to implement these interventions in the community setting.

Original languageEnglish (US)
Pages (from-to)126-139
Number of pages14
JournalAmerican Journal of Preventive Medicine
Volume28
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Weight Loss
Weights and Measures
Confidence Intervals
Outcome Assessment (Health Care)
Bibliographic Databases
Glucose Intolerance
Incidence
Population Characteristics
Type 2 Diabetes Mellitus
Fasting
Body Mass Index
Language
Randomized Controlled Trials
Body Weight
Blood Pressure
Morbidity
Lipids
Glucose
Control Groups
Mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health

Cite this

Long-term effectiveness of weight-loss interventions in adults with pre-diabetes : A review. / Norris, Susan L.; Zhang, Xuanping; Avenell, Alison; Gregg, Edward; Bowman, Barbara; Schmid, Christopher H.; Lau, Joseph.

In: American Journal of Preventive Medicine, Vol. 28, No. 1, 01.2005, p. 126-139.

Research output: Contribution to journalArticle

Norris, SL, Zhang, X, Avenell, A, Gregg, E, Bowman, B, Schmid, CH & Lau, J 2005, 'Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: A review', American Journal of Preventive Medicine, vol. 28, no. 1, pp. 126-139. https://doi.org/10.1016/j.amepre.2004.08.006
Norris, Susan L. ; Zhang, Xuanping ; Avenell, Alison ; Gregg, Edward ; Bowman, Barbara ; Schmid, Christopher H. ; Lau, Joseph. / Long-term effectiveness of weight-loss interventions in adults with pre-diabetes : A review. In: American Journal of Preventive Medicine. 2005 ; Vol. 28, No. 1. pp. 126-139.
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