Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms

C. Lüscher, Matthew Frerking

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages527-532
Number of pages6
ISBN (Print)9780080450469
DOIs
Publication statusPublished - 2010

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lüscher, C., & Frerking, M. (2010). Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms. In Encyclopedia of Neuroscience (pp. 527-532). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01205-5