Long-Term Depression (LTD)

Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms

C. Lüscher, Matthew Frerking

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages527-532
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

Metabotropic Glutamate Receptors
Glutamate Receptors
N-Methylaspartate
Synaptic Transmission
Synapses
Maintenance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lüscher, C., & Frerking, M. (2010). Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms. In Encyclopedia of Neuroscience (pp. 527-532). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01205-5

Long-Term Depression (LTD) : Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms. / Lüscher, C.; Frerking, Matthew.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 527-532.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lüscher, C & Frerking, M 2010, Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 527-532. https://doi.org/10.1016/B978-008045046-9.01205-5
Lüscher, C. ; Frerking, Matthew. / Long-Term Depression (LTD) : Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 527-532
@inbook{cd06cc69a8f6420598820bf8fd92422a,
title = "Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms",
abstract = "Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.",
author = "C. L{\"u}scher and Matthew Frerking",
year = "2010",
doi = "10.1016/B978-008045046-9.01205-5",
language = "English (US)",
isbn = "9780080450469",
pages = "527--532",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Long-Term Depression (LTD)

T2 - Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms

AU - Lüscher, C.

AU - Frerking, Matthew

PY - 2010

Y1 - 2010

N2 - Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.

AB - Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.

UR - http://www.scopus.com/inward/record.url?scp=84882891119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882891119&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.01205-5

DO - 10.1016/B978-008045046-9.01205-5

M3 - Chapter

SN - 9780080450469

SP - 527

EP - 532

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -