TY - JOUR
T1 - Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses
AU - Lazarevic, Vanja
AU - Nolt, Dawn
AU - Flynn, Jo Anne L.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/7/15
Y1 - 2005/7/15
N2 - The primary goal of this study was to determine how chronic exposure to Ag influences the functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-γ-producing effector CD4+ and CD8+ T cells dynamically changed during persistent M. tuberculosis infection. CD8+ T cells used differential effector functions during acute and chronic phases of the immune response, where CD8+ T cells produced negligible amounts of IFN-α early in infection, but switched to cytokine production during the chronic stage of infection. Using limiting dilution analysis, CD8+ T cells isolated during the initial phase of infection demonstrated lytic potential, but this waned in the chronic stage. The apparent loss of cytotoxic activity was not associated with the lack of perforin. Ag dose could potentially govern the functional program of CD8 + T cells. Collectively, these results depict a host immune response mounted against M. tuberculosis of a significantly more dynamic nature than previously recognized.
AB - The primary goal of this study was to determine how chronic exposure to Ag influences the functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-γ-producing effector CD4+ and CD8+ T cells dynamically changed during persistent M. tuberculosis infection. CD8+ T cells used differential effector functions during acute and chronic phases of the immune response, where CD8+ T cells produced negligible amounts of IFN-α early in infection, but switched to cytokine production during the chronic stage of infection. Using limiting dilution analysis, CD8+ T cells isolated during the initial phase of infection demonstrated lytic potential, but this waned in the chronic stage. The apparent loss of cytotoxic activity was not associated with the lack of perforin. Ag dose could potentially govern the functional program of CD8 + T cells. Collectively, these results depict a host immune response mounted against M. tuberculosis of a significantly more dynamic nature than previously recognized.
UR - http://www.scopus.com/inward/record.url?scp=23244432880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23244432880&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.175.2.1107
DO - 10.4049/jimmunol.175.2.1107
M3 - Article
C2 - 16002712
AN - SCOPUS:23244432880
SN - 0022-1767
VL - 175
SP - 1107
EP - 1117
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -