Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex

Tianyi Mao, Deniz Kusefoglu, Bryan M. Hooks, Daniel Huber, Leopoldo Petreanu, Karel Svoboda

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

In the rodent vibrissal system, active sensation and sensorimotor integration are mediated in part by connections between barrel cortex and vibrissal motor cortex. Little is known about how these structures interact at the level of neurons. We used Channelrhodopsin-2 (ChR2) expression, combined with anterograde and retrograde labeling, to map connections between barrel cortex and pyramidal neurons in mouse motor cortex. Barrel cortex axons preferentially targeted upper layer (L2/3, L5A) neurons in motor cortex; input to neurons projecting back to barrel cortex was particularly strong. Barrel cortex input to deeper layers (L5B, L6) of motor cortex, including neurons projecting to the brainstem, was weak, despite pronounced geometric overlap of dendrites with axons from barrel cortex. Neurons in different layers received barrel cortex input within stereotyped dendritic domains. The cortico-cortical neurons in superficial layers of motor cortex thus couple motor and sensory signals and might mediate sensorimotor integration and motor learning.

Original languageEnglish (US)
Pages (from-to)111-123
Number of pages13
JournalNeuron
Volume72
Issue number1
DOIs
StatePublished - Oct 6 2011
Externally publishedYes

Fingerprint

Motor Cortex
Neurons
Axons
Pyramidal Cells
Dendrites
Brain Stem
Sensorimotor Cortex
Rodentia
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mao, T., Kusefoglu, D., Hooks, B. M., Huber, D., Petreanu, L., & Svoboda, K. (2011). Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex. Neuron, 72(1), 111-123. https://doi.org/10.1016/j.neuron.2011.07.029

Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex. / Mao, Tianyi; Kusefoglu, Deniz; Hooks, Bryan M.; Huber, Daniel; Petreanu, Leopoldo; Svoboda, Karel.

In: Neuron, Vol. 72, No. 1, 06.10.2011, p. 111-123.

Research output: Contribution to journalArticle

Mao, T, Kusefoglu, D, Hooks, BM, Huber, D, Petreanu, L & Svoboda, K 2011, 'Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex', Neuron, vol. 72, no. 1, pp. 111-123. https://doi.org/10.1016/j.neuron.2011.07.029
Mao, Tianyi ; Kusefoglu, Deniz ; Hooks, Bryan M. ; Huber, Daniel ; Petreanu, Leopoldo ; Svoboda, Karel. / Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex. In: Neuron. 2011 ; Vol. 72, No. 1. pp. 111-123.
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