Long-latency neurodegenerative disease in the western Pacific.

Peter Spencer, G. E. Kisby, A. C. Ludolph

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The western Pacific parkinsonism-dementia and amyotrophic lateral sclerosis complex is a prototypical neurodegenerative disorder found among inhabitants of Guam, New Guinea (Irian Jaya, Indonesia) and Japan (Kii Peninsula, Honshu). Nonviral environmental factors peculiar to the affected populations seem to play a prominent etiologic role. Although cause-effect relationships cannot be established by epidemiologic studies alone, we have shown in all three affected population groups that individuals develop the amyotrophic lateral sclerosis variant of this disorder after heavy exposure to the raw or incompletely detoxified seed of neurotoxic cycad plants. Since long periods may elapse between cycad exposure and the appearance of neurological disease in humans, cycads may harbor a "slow toxin" that causes the postmitotic neuron to undergo slow irreversible degeneration. Two cycad neurotoxins are recognized, one of which (cycasin) is known to have long-latency effects (tumorigenesis) on mitotic neurons and replicating cells in other tissues. This paper explores the possible relationship between tumorigenesis and long-latency neurotoxicity, and discusses possible biologic markers of cycad exposure and subclinical neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalGeriatrics
Volume46 Suppl 1
StatePublished - Aug 1991

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Indonesia
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Cycasin
Carcinogenesis
Guam
New Guinea
Neurons
Neurotoxins
Parkinsonian Disorders
Population Groups
Dementia
Epidemiologic Studies
Seeds
Japan
Biomarkers
Population

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Spencer, P., Kisby, G. E., & Ludolph, A. C. (1991). Long-latency neurodegenerative disease in the western Pacific. Geriatrics, 46 Suppl 1, 37-42.

Long-latency neurodegenerative disease in the western Pacific. / Spencer, Peter; Kisby, G. E.; Ludolph, A. C.

In: Geriatrics, Vol. 46 Suppl 1, 08.1991, p. 37-42.

Research output: Contribution to journalArticle

Spencer, P, Kisby, GE & Ludolph, AC 1991, 'Long-latency neurodegenerative disease in the western Pacific.', Geriatrics, vol. 46 Suppl 1, pp. 37-42.
Spencer, Peter ; Kisby, G. E. ; Ludolph, A. C. / Long-latency neurodegenerative disease in the western Pacific. In: Geriatrics. 1991 ; Vol. 46 Suppl 1. pp. 37-42.
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