Long-duration response to levodopa

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

We measured the long-duration response to levodopa by changes in tapping rate in 16 patients with Parkinson's disease undergoing 3 to 5 days of levodopa withdrawal. ``Off'' tapping rates deteriorated 22% over the course of this holiday, the decline beginning 24 hours after levodopa withdrawal. Deterioration was more pronounced in the more affected hand in asymmetrically affected patients. A 2-hour infusion of levodopa after the levodopa holiday did not restore the long-duration response, although it produced a greater short-duration response than before the holiday. These observations indicate that the long-duration response is an important component of the therapeutic benefit of levodopa and is separable from the short-duration response.

Original languageEnglish (US)
Pages (from-to)1613-1616
Number of pages4
JournalNeurology
Volume45
Issue number8
StatePublished - 1995

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Levodopa
Holidays
Hand
Tapping

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Long-duration response to levodopa. / Nutt, John; Carter, Julie; Woodward, William.

In: Neurology, Vol. 45, No. 8, 1995, p. 1613-1616.

Research output: Contribution to journalArticle

Nutt, J, Carter, J & Woodward, W 1995, 'Long-duration response to levodopa', Neurology, vol. 45, no. 8, pp. 1613-1616.
Nutt, John ; Carter, Julie ; Woodward, William. / Long-duration response to levodopa. In: Neurology. 1995 ; Vol. 45, No. 8. pp. 1613-1616.
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