Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques

Selva L. Luna, Donald I. Brown, Dominique H. Eghlidi, Steven Kohama, Henryk Urbanski

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Reduced activity has been linked to age-associated physiological changes but the underlying root cause is unclear. The goal of the present study was to compare the orexin neuronal system of old (23–29 years) female rhesus macaques with either active or sedentary 24-hour locomotor activity patterns. Using immunohistochemistry, we counted the number of orexin A and orexin B neurons in the lateral hypothalamic area of each animal. Overall, we observed no difference in the distribution pattern or number of either orexin A or orexin B immune-positive neurons between animals in the 2 groups. Thus, reduced activity in the elderly is unlikely to stem from a loss of orexin neuronal perikarya in the lateral hypothalamic area. This, however, does not rule out the possibility that the reduced activity stems from reduced orexin neuronal projections to arousal centers of the brain, such as the locus coeruleus, or from attenuated release of orexin.

    Original languageEnglish (US)
    Pages (from-to)1-4
    Number of pages4
    JournalNeurobiology of Aging
    Volume50
    DOIs
    StatePublished - Feb 1 2017

    Fingerprint

    Locomotion
    Macaca mulatta
    Lateral Hypothalamic Area
    Neurons
    Locus Coeruleus
    Arousal
    Immunohistochemistry
    Orexins
    Brain

    Keywords

    • Aging
    • cFOS
    • Hypocretin
    • Lateral hypothalamic area (LHA)
    • Orexin
    • Rhesus macaque

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Aging
    • Developmental Biology
    • Geriatrics and Gerontology
    • Clinical Neurology

    Cite this

    Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques. / Luna, Selva L.; Brown, Donald I.; Eghlidi, Dominique H.; Kohama, Steven; Urbanski, Henryk.

    In: Neurobiology of Aging, Vol. 50, 01.02.2017, p. 1-4.

    Research output: Contribution to journalArticle

    Luna, Selva L. ; Brown, Donald I. ; Eghlidi, Dominique H. ; Kohama, Steven ; Urbanski, Henryk. / Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques. In: Neurobiology of Aging. 2017 ; Vol. 50. pp. 1-4.
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    AU - Kohama, Steven

    AU - Urbanski, Henryk

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