Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

John Belknap, J. S. Mogil, M. L. Helms, S. P. Richards, L. A. O'Toole, S. E. Bergeson, Kari Buck

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Abstract

A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (Rl) strains and in an F2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p

Original languageEnglish (US)
JournalLife Sciences
Volume57
Issue number10
DOIs
Publication statusPublished - Jul 28 1995

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Keywords

  • analgesia
  • BXD
  • C57BL/6
  • DBA/2
  • opioid receptors
  • QTL mapping

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

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