Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains

John Belknap, J. S. Mogil, M. L. Helms, S. P. Richards, L. A. O'Toole, S. E. Bergeson, Kari Buck

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (Rl) strains and in an F2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p

Original languageEnglish (US)
JournalLife Sciences
Volume57
Issue number10
DOIs
StatePublished - Jul 28 1995

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Chromosomes, Human, Pair 10
Quantitative Trait Loci
Chromosomes
Analgesia
Morphine

Keywords

  • analgesia
  • BXD
  • C57BL/6
  • DBA/2
  • opioid receptors
  • QTL mapping

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

Cite this

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains. / Belknap, John; Mogil, J. S.; Helms, M. L.; Richards, S. P.; O'Toole, L. A.; Bergeson, S. E.; Buck, Kari.

In: Life Sciences, Vol. 57, No. 10, 28.07.1995.

Research output: Contribution to journalArticle

Belknap, John ; Mogil, J. S. ; Helms, M. L. ; Richards, S. P. ; O'Toole, L. A. ; Bergeson, S. E. ; Buck, Kari. / Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/ and DBA/2 strains. In: Life Sciences. 1995 ; Vol. 57, No. 10.
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AU - O'Toole, L. A.

AU - Bergeson, S. E.

AU - Buck, Kari

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