Localization of3h-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus

Barbara J. Wilcox, Murray A. Raskind, Grant N. Ko, Denis G. Baskin, Marcella Pascualy, Daniel M. Dorsa

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Using3H-prazosin, we have examined the distribution of α1-adrenergic receptors in the supraoptic and paraventricular nuclei of the human hypothalamus. Our studies show that binding sites for3H-prazosin in human hypothalamus possess pharmacological characteristics similar to those of rat brain. Autoradiographic studies revealed discrete localization of3H-prazosin to the paraventricular and supraoptic nuclei.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalNeuroendocrinology
Volume51
Issue number3
DOIs
StatePublished - Jan 1 1990

Keywords

  • Human hypothalamus
  • Paraventricular nucleus
  • Prazosin
  • Supraoptic nucleus
  • α-Receptors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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