Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B

Dennis Schultz, Michael Litt, Leslie Smith, Mathew (Matt) Thayer, Ken Mccormack

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The gating properties and current amplitudes of mammalian voltage- activated Shaker potassium channels are modulated by at least two associated β subunits (Kvβ1.1 and Kvβ1.2). The human Kvβ1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kvβ1.2 gene (KCNA2β) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3.

Original languageEnglish (US)
Pages (from-to)389-391
Number of pages3
JournalGenomics
Volume31
Issue number3
DOIs
StatePublished - Feb 1 1996

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Hybrid Cells
Potassium Channels
Fluorescence In Situ Hybridization
Shaker Superfamily of Potassium Channels
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Genes
Libraries
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics

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Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B. / Schultz, Dennis; Litt, Michael; Smith, Leslie; Thayer, Mathew (Matt); Mccormack, Ken.

In: Genomics, Vol. 31, No. 3, 01.02.1996, p. 389-391.

Research output: Contribution to journalArticle

Schultz, Dennis ; Litt, Michael ; Smith, Leslie ; Thayer, Mathew (Matt) ; Mccormack, Ken. / Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B. In: Genomics. 1996 ; Vol. 31, No. 3. pp. 389-391.
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