Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q

Stephen W. Scherer, Robert M. Duvoisin, Rainer Kuhn, Henry H.Q. Heng, Elena Belloni, Lap Chee Tsui

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to he integrated into the genetic and physical map of chromosome 7.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalGenomics
Volume31
Issue number2
DOIs
StatePublished - Jan 15 1996

ASJC Scopus subject areas

  • Genetics

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