Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q

Stephen W. Scherer, Robert Duvoisin, Rainer Kuhn, Henry H Q Heng, Elena Belloni, Lap Chee Tsui

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Abstract

Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to he integrated into the genetic and physical map of chromosome 7.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalGenomics
Volume31
Issue number2
DOIs
Publication statusPublished - Jan 15 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

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