Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems

Clare Seaman, Richard Anderson, Ben Emery, Helen M. Cooper

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Over recent years the secreted guidance cue, netrin-1, and its receptor, DCC, have been shown to be an essential guidance system driving axon pathfinding within the developing vertebrate central nervous system (CNS). Mice lacking DCC exhibit severe defects in commissural axon extension towards the floor plate demonstrating that the DCC-netrin guidance system is largely responsible for directing axonal projections toward the ventral midline in the developing spinal cord (Fazeli et al., Nature 386 (1997) 796). In addition, these mutants lack several major commissures within the forebrain, including the corpus callosum and the hippocampal commissure. In contrast to the CNS, the role of the DCC guidance receptor in the development of the mammalian peripheral and enteric nervous systems (PNS and ENS) has not been investigated. Here we demonstrate using immunohistochemical analysis that the DCC receptor is present in the developing mouse PNS where it is found on spinal, segmental, and sciatic nerves, and in developing sensory ganglia and their associated axonal projections. In addition, DCC is present in the ENS throughout the early developmental phase.

Original languageEnglish (US)
Pages (from-to)173-175
Number of pages3
JournalMechanisms of Development
Volume103
Issue number1-2
DOIs
StatePublished - May 2001

Keywords

  • Axon guidance
  • DCC
  • Development
  • Enteric nervous system
  • Netrin
  • Peripheral nervous system
  • Sensory ganglia

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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