Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

Z. W. Ma; T. Pejovic; V. Najfeld; D. C. Ward; Edward M. Johnson

doi:10.1159/000134065

Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

Z. W. Ma, T. Pejovic, V. Najfeld, D. C. Ward, Edward M. Johnson

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Cytogenetics and Cell Genetics
Volume	71
Issue number	1
DOIs	https://doi.org/10.1159/000134065
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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abstract = "Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.",

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year = "1995",

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AU - Pejovic, T.

AU - Najfeld, V.

AU - Ward, D. C.

AU - Johnson, Edward M.

PY - 1995

Y1 - 1995

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AB - Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

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Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

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