Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

Z. W. Ma, Tanja Pejovic, V. Najfeld, D. C. Ward, Edward M. Johnson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalCytogenetic and Genome Research
Volume71
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

DNA-Binding Proteins
Human Chromosomes
Chromosomes
Myeloid Leukemia
Sequence Homology
Fluorescence In Situ Hybridization
DNA Replication
Cricetinae
Genes
Complementary DNA
Cell Line
DNA
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31. / Ma, Z. W.; Pejovic, Tanja; Najfeld, V.; Ward, D. C.; Johnson, Edward M.

In: Cytogenetic and Genome Research, Vol. 71, No. 1, 1995, p. 64-67.

Research output: Contribution to journalArticle

@article{c45754d99c184cc6a52600cfce6832e3,
title = "Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31",
abstract = "Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.",
author = "Ma, {Z. W.} and Tanja Pejovic and V. Najfeld and Ward, {D. C.} and Johnson, {Edward M.}",
year = "1995",
doi = "10.1159/000134065",
language = "English (US)",
volume = "71",
pages = "64--67",
journal = "Cytogenetic and Genome Research",
issn = "1424-8581",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

AU - Ma, Z. W.

AU - Pejovic, Tanja

AU - Najfeld, V.

AU - Ward, D. C.

AU - Johnson, Edward M.

PY - 1995

Y1 - 1995

N2 - Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

AB - Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

UR - http://www.scopus.com/inward/record.url?scp=0029039088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029039088&partnerID=8YFLogxK

U2 - 10.1159/000134065

DO - 10.1159/000134065

M3 - Article

VL - 71

SP - 64

EP - 67

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

SN - 1424-8581

IS - 1

ER -