Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Purα, to chromosome band 5q31

Z. W. Ma, T. Pejovic, V. Najfeld, D. C. Ward, Edward M. Johnson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purα (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Purα gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6ql4. The 5q31 locus is frequently deleted in myelogenous leukemias and other cancers.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalCytogenetic and Genome Research
Volume71
Issue number1
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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