Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

M. Litt, J. Luty, M. Kwak, L. Allen, R. E. Magenis, G. Mandel

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the α-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalGenomics
Volume5
Issue number2
DOIs
StatePublished - Aug 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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