Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31

Torbjoern G. Nygaard, Deborah Raymond, Caiping Chen, Ichizo Nishino, Paul E. Greene, Danna Jennings, Gary A. Heiman, Christine Klein, Rachel J. Saunders-Pullman, Patricia Kramer, Laurie J. Ozelius, Susan B. Bressman

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Essential myoclonus-dystonia is a neurological condition characterized by myoclonic and dystonic muscle contractions and the absence of other neurological signs or laboratory abnormalities; it is often responsive to alcohol. The disorder may be familial with apparent autosomal dominant inheritance. We report a large kindred with essential familial myoclonus- dystonia and map a locus for the disorder to a 28-cM region of chromosome 7q21-q31.

Original languageEnglish (US)
Pages (from-to)794-798
Number of pages5
JournalAnnals of Neurology
Volume46
Issue number5
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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