Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31

Torbjoern G. Nygaard, Deborah Raymond, Caiping Chen, Ichizo Nishino, Paul E. Greene, Danna Jennings, Gary A. Heiman, Christine Klein, Rachel J. Saunders-Pullman, Patricia Kramer, Laurie J. Ozelius, Susan B. Bressman

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Essential myoclonus-dystonia is a neurological condition characterized by myoclonic and dystonic muscle contractions and the absence of other neurological signs or laboratory abnormalities; it is often responsive to alcohol. The disorder may be familial with apparent autosomal dominant inheritance. We report a large kindred with essential familial myoclonus- dystonia and map a locus for the disorder to a 28-cM region of chromosome 7q21-q31.

Original languageEnglish (US)
Pages (from-to)794-798
Number of pages5
JournalAnnals of Neurology
Volume46
Issue number5
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Nygaard, T. G., Raymond, D., Chen, C., Nishino, I., Greene, P. E., Jennings, D., Heiman, G. A., Klein, C., Saunders-Pullman, R. J., Kramer, P., Ozelius, L. J., & Bressman, S. B. (1999). Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31. Annals of Neurology, 46(5), 794-798. https://doi.org/10.1002/1531-8249(199911)46:5<794::AID-ANA19>3.0.CO;2-2