Localization and measurement of neurotransmitter receptors in rat and human brain by quantitative autoradiography

G. N. Ko, B. J. Wilco, F. M. Petracca, M. A. Miller, M. M. Murburg, D. G. Baskin, Daniel Dorsa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Receptors for neurotransmitters can be visualized and characterized using in vitro tissue slice binding techniques and quantitative autoradiography. In this article, the general methods used in studies of this type are outlined and specific application to the study of catecholamine and neuropeptide receptors in rat and human brain tissue are described. Receptor autoradiography is used to examine regulation of dopamine receptor density in response to denervation and replacement of dopamine using brain transplants. Morphological and pharmacological aspects of vasopressin receptor ontogeny in the rat brain are examined. Finally, autoradiographic data on catecholamine receptor localization and characterization in the human hypothalamus, locus coeruleus, and frontal cortex are presented and discussed with reference to their applications in the study of neuropsychiatric disorders such as schizophrenia and senile dementia of the Alzheimer's type.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalComputerized Medical Imaging and Graphics
Volume13
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Neurotransmitter Receptor
Catecholamine Receptors
Autoradiography
Rats
Brain
Neuropeptide Receptors
Tissue
Vasopressin Receptors
Transplants
Locus Coeruleus
Dopamine Receptors
Frontal Lobe
Denervation
Hypothalamus
Dopamine
Schizophrenia
Alzheimer Disease
Pharmacology
Catecholamines

Keywords

  • Alpha adrenergic
  • Alzheimer's disease
  • Autoradiography
  • Catecholamine
  • Frontal cortex
  • Hypothalamus
  • Locus coeruleus
  • Receptors
  • Schizophrenia
  • Vasopressin

ASJC Scopus subject areas

  • Computer Science Applications
  • Radiology Nuclear Medicine and imaging

Cite this

Localization and measurement of neurotransmitter receptors in rat and human brain by quantitative autoradiography. / Ko, G. N.; Wilco, B. J.; Petracca, F. M.; Miller, M. A.; Murburg, M. M.; Baskin, D. G.; Dorsa, Daniel.

In: Computerized Medical Imaging and Graphics, Vol. 13, No. 1, 1989, p. 37-45.

Research output: Contribution to journalArticle

Ko, G. N. ; Wilco, B. J. ; Petracca, F. M. ; Miller, M. A. ; Murburg, M. M. ; Baskin, D. G. ; Dorsa, Daniel. / Localization and measurement of neurotransmitter receptors in rat and human brain by quantitative autoradiography. In: Computerized Medical Imaging and Graphics. 1989 ; Vol. 13, No. 1. pp. 37-45.
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