Localization and characterization of vasopressin-binding sites in the amygdala of the rat brain

D. M. Dorsa, F. M. Petracca, D. G. Baskin, L. E. Cornett

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Abstract

Putative receptors for arginine8-vasopressin (AVP) in rat brain were localized and characterized using autoradiographic and radioligand-binding techniques. When brain slices were incubated with tritium-labeled vasopressin, an intense concentration of binding sites was identified which included the medial aspects of the amygdala. Binding of labeled AVP to membrane preparations from this brain ragion was saturable, specific, reversible, and of high affinity. An antagonist of the peripheral pressor activity of vasopressin was found to be a potent competitor for binding to this site.

Original languageEnglish (US)
Pages (from-to)1764-1770
Number of pages7
JournalJournal of Neuroscience
Volume4
Issue number7
StatePublished - Dec 1 1984

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ASJC Scopus subject areas

  • Neuroscience(all)

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