Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Bahareh Ajami, Jami L. Bennett, Charles Krieger, Wolfram Tetzlaff, Fabio M.V. Rossi

Research output: Contribution to journalArticlepeer-review

951 Scopus citations

Abstract

Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.

Original languageEnglish (US)
Pages (from-to)1538-1543
Number of pages6
JournalNature Neuroscience
Volume10
Issue number12
DOIs
StatePublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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