Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia: Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining

Zhenhong Qu, Cesar Hernandez Garcia, Leslie M. O'Rourke, Stephen Planck, Manoj Kohli, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Objective. To test the hypothesis that local proliferation contributes significantly to the hyperplasia of rheumatoid synovium. Methods. Immunohistologic and chemical staining was used to identify 3 markers of cell proliferation: proliferating cell nuclear antigen, c-myc proto-oncogene, and nucleolar organizer regions. Synovium from 21 patients with rheumatoid arthritis, 34 with degenerative joint disease, and 7 with joint trauma was examined. Results. All 3 markers indicated substantial, active proliferation of synovial lining cells in synovium with hyperplasia. Proliferating cells showed type I procollagen immunoreactivity but were negative for CD68, a monocyte/macrophage marker. Proliferation was greater in rheumatoid arthritis than in the other conditions evaluated. Conclusion. In situ proliferation of fibroblast-like synoviocytes in the synovium lining contributes considerably to the increase in cell numbers in rheumatoid synovium.

Original languageEnglish (US)
Pages (from-to)212-220
Number of pages9
JournalArthritis and Rheumatism
Volume37
Issue number2
StatePublished - Feb 1994

Fingerprint

Nucleolus Organizer Region
Cyclins
Synovial Membrane
Proliferating Cell Nuclear Antigen
Hyperplasia
Fibroblasts
Staining and Labeling
Rheumatoid Arthritis
myc Genes
Collagen Type I
Osteoarthritis
Monocytes
Cell Count
Joints
Macrophages
Cell Proliferation
Synoviocytes
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia : Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. / Qu, Zhenhong; Hernandez Garcia, Cesar; O'Rourke, Leslie M.; Planck, Stephen; Kohli, Manoj; Rosenbaum, James (Jim).

In: Arthritis and Rheumatism, Vol. 37, No. 2, 02.1994, p. 212-220.

Research output: Contribution to journalArticle

@article{525cfa98a5ec423190ba86042df6e254,
title = "Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia: Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining",
abstract = "Objective. To test the hypothesis that local proliferation contributes significantly to the hyperplasia of rheumatoid synovium. Methods. Immunohistologic and chemical staining was used to identify 3 markers of cell proliferation: proliferating cell nuclear antigen, c-myc proto-oncogene, and nucleolar organizer regions. Synovium from 21 patients with rheumatoid arthritis, 34 with degenerative joint disease, and 7 with joint trauma was examined. Results. All 3 markers indicated substantial, active proliferation of synovial lining cells in synovium with hyperplasia. Proliferating cells showed type I procollagen immunoreactivity but were negative for CD68, a monocyte/macrophage marker. Proliferation was greater in rheumatoid arthritis than in the other conditions evaluated. Conclusion. In situ proliferation of fibroblast-like synoviocytes in the synovium lining contributes considerably to the increase in cell numbers in rheumatoid synovium.",
author = "Zhenhong Qu and {Hernandez Garcia}, Cesar and O'Rourke, {Leslie M.} and Stephen Planck and Manoj Kohli and Rosenbaum, {James (Jim)}",
year = "1994",
month = "2",
language = "English (US)",
volume = "37",
pages = "212--220",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia

T2 - Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining

AU - Qu, Zhenhong

AU - Hernandez Garcia, Cesar

AU - O'Rourke, Leslie M.

AU - Planck, Stephen

AU - Kohli, Manoj

AU - Rosenbaum, James (Jim)

PY - 1994/2

Y1 - 1994/2

N2 - Objective. To test the hypothesis that local proliferation contributes significantly to the hyperplasia of rheumatoid synovium. Methods. Immunohistologic and chemical staining was used to identify 3 markers of cell proliferation: proliferating cell nuclear antigen, c-myc proto-oncogene, and nucleolar organizer regions. Synovium from 21 patients with rheumatoid arthritis, 34 with degenerative joint disease, and 7 with joint trauma was examined. Results. All 3 markers indicated substantial, active proliferation of synovial lining cells in synovium with hyperplasia. Proliferating cells showed type I procollagen immunoreactivity but were negative for CD68, a monocyte/macrophage marker. Proliferation was greater in rheumatoid arthritis than in the other conditions evaluated. Conclusion. In situ proliferation of fibroblast-like synoviocytes in the synovium lining contributes considerably to the increase in cell numbers in rheumatoid synovium.

AB - Objective. To test the hypothesis that local proliferation contributes significantly to the hyperplasia of rheumatoid synovium. Methods. Immunohistologic and chemical staining was used to identify 3 markers of cell proliferation: proliferating cell nuclear antigen, c-myc proto-oncogene, and nucleolar organizer regions. Synovium from 21 patients with rheumatoid arthritis, 34 with degenerative joint disease, and 7 with joint trauma was examined. Results. All 3 markers indicated substantial, active proliferation of synovial lining cells in synovium with hyperplasia. Proliferating cells showed type I procollagen immunoreactivity but were negative for CD68, a monocyte/macrophage marker. Proliferation was greater in rheumatoid arthritis than in the other conditions evaluated. Conclusion. In situ proliferation of fibroblast-like synoviocytes in the synovium lining contributes considerably to the increase in cell numbers in rheumatoid synovium.

UR - http://www.scopus.com/inward/record.url?scp=0342425883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342425883&partnerID=8YFLogxK

M3 - Article

C2 - 7510485

AN - SCOPUS:0342425883

VL - 37

SP - 212

EP - 220

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 2

ER -