Local detection of prostate cancer by positron emission tomography with 2-fluorodeoxyglucose: Comparison of filtered back projection and iterative reconstruction with segmented attenuation correction

A. Turlakow, S. M. Larson, Fergus Coakley, T. Akhurst, M. Gonen, H. A. Macapinlac, W. Kelly, S. Leibel, J. Humm, P. Scardino, H. Scher, H. Hricak

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background. To compare filtered back projection (FBP) and iterative reconstruction with segmented attenuation correction (IRSAC) in the local imaging of prostate cancer by positron emission tomography with 2-fluorodeoxyglucose (FDG-PET). Methods. We retrospectively identified 13 patients with primary (n=7) or recurrent (n=6) prostate cancer who had increased uptake in the prostate on FDG-PET performed without urinary catheterization, contemporaneous biopsy confirming the presence of active tumor in the prostate, and correlative cross-sectional imaging by MRI (n=8) or CT (n=5). FDG-PET images were reconstructed by FBP and IRSAC. Two independent nuclear medicine physicians separately rated FBP and IRSAC images for visualization of prostatic activity on a 4-point scale. Results were compared using biopsy and cross-sectional imaging findings as the standard of reference. Results. IRSAC images were significantly better that FBP in terms of visualization of prostatic activity in 12 of 13 patients, and were equivalent in 1 patient (p

Original languageEnglish (US)
Pages (from-to)235-244
Number of pages10
JournalQuarterly Journal of Nuclear Medicine
Volume45
Issue number3
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Fludeoxyglucose F18
  • Prostatic neoplasms, radionuclide imaging
  • Tomography, emission computed

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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