Lobeline effects on tonic and methamphetamine-induced dopamine release

Clare J. Wilhelm, Robert A. Johnson, Amy J. Eshleman, Aaron Janowsky

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The mechanisms of interaction between lobeline and the dopamine transporter (DAT) or the vesicular monoamine transporter (VMAT-2) are not clear. The goal of this study was to elucidate the effects of lobeline on these transporters in a cell system co-expressing the DAT and VMAT-2. Lobeline caused release of [3H]dopamine to a similar extent as reserpine (VMAT-2 inhibitor), but was less efficacious than methamphetamine or dopamine. Additionally, lobeline decreased the [3H]dopamine-releasing effects of methamphetamine, unlike reserpine which increased release by methamphetamine. These results suggest that lobeline has unique properties at the DAT and VMAT-2 which may make it useful as a pharmacotherapeutic to treat methamphetamine abuse.

Original languageEnglish (US)
Pages (from-to)1411-1415
Number of pages5
JournalBiochemical Pharmacology
Volume75
Issue number6
DOIs
StatePublished - Mar 15 2008

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Keywords

  • Dopamine
  • Dopamine transporter
  • Lobeline
  • Methamphetamine
  • Vesicular monoamine transporter

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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