TY - JOUR
T1 - Liver injury in patients with COVID-19
T2 - clinical profiles, CT findings, the correlation of the severity with liver injury
AU - Lei, Ping
AU - Zhang, Lan
AU - Han, Ping
AU - Zheng, Chuansheng
AU - Tong, Qiaoxia
AU - Shang, Haitao
AU - Yang, Fan
AU - Hu, Yu
AU - Li, Xin
AU - Song, Yuhu
N1 - Funding Information:
We thank Dr Hui Guo (Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, HUST), Dr Cen Chen (Department of Radiology, Union Hospital, Tongji Medical College, HUST) for kind assistance in the collection of laboratory data, and Mr. Bo Rao (School of Electric and Electronical Engineering, HUST), Dr Yu Shi (Departments of Radiology, Shengjing Hospital, China Medical University) for helpful suggestions in statistical analysis.
Funding Information:
This work was supported by the Key Special Project of Ministry of Science and Technology, China (No. 2020YFC0845700), the Emergency Projects of Science and Technology Department of Hubei Province (No.2020FCA014); COVID-19 Rapid Response Call of Huazhong University of Science and Technology (No.2020kfyXGYJ021 and 2020kfyXGYJ026), and National Natural Science Foundation of China (81570555). Acknowledgements
Publisher Copyright:
© 2020, Asian Pacific Association for the Study of the Liver.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background and aims: Liver injury is found in some of patients with COVID-19. Liver injury of COVID-19 patients based on severity grading and abdominal radiological signs have not been reported until now. The aim of our study is to determine clinical profiles of the patients based on severity grading, describe abdominal radiological signs, and investigate the correlations of the severity with clinical profiles and radiological signs. Methods: This retrospective cohort study included 115 patients with COVID-19 from Jan 2020 to Feb 2020. Medical records of the patients were collected and CT images were reviewed. Results: Common clinical manifestations of patients with COVID-19 were fever (68.70%), cough (56.52%), fatigue (31.30%); some of them had gastrointestinal symptoms (diarrhea, 12.17%; nausea or vomiting 7.83%; inappetence, 7.83%). Abnormal liver function was observed in some of patients with COVID-19. Significant differences in the levels of AST, albumin,CRP were observed among different groups classified by the severity. Common findings of upper abdominal CT scan were liver hypodensity (26.09%) and pericholecystic fat stranding (21.27%); liver hypodensity was more frequently found in critical cases (58.82%). The severity of COVID-19 correlated with semi-quantitative CT score of pulmonary lesions, CT-quantified liver/spleen attenuation ratio in patients with COVID-19. Conclusions: Some of the patients with COVID-19 displayed liver damage revealed by liver functional tests and upper abdominal CT imaging, and the severity of COVID-19 patients correlated with some of liver functional tests and CT signs; thus, it will allow an earlier identification of high-risk patients for early effective intervention.
AB - Background and aims: Liver injury is found in some of patients with COVID-19. Liver injury of COVID-19 patients based on severity grading and abdominal radiological signs have not been reported until now. The aim of our study is to determine clinical profiles of the patients based on severity grading, describe abdominal radiological signs, and investigate the correlations of the severity with clinical profiles and radiological signs. Methods: This retrospective cohort study included 115 patients with COVID-19 from Jan 2020 to Feb 2020. Medical records of the patients were collected and CT images were reviewed. Results: Common clinical manifestations of patients with COVID-19 were fever (68.70%), cough (56.52%), fatigue (31.30%); some of them had gastrointestinal symptoms (diarrhea, 12.17%; nausea or vomiting 7.83%; inappetence, 7.83%). Abnormal liver function was observed in some of patients with COVID-19. Significant differences in the levels of AST, albumin,CRP were observed among different groups classified by the severity. Common findings of upper abdominal CT scan were liver hypodensity (26.09%) and pericholecystic fat stranding (21.27%); liver hypodensity was more frequently found in critical cases (58.82%). The severity of COVID-19 correlated with semi-quantitative CT score of pulmonary lesions, CT-quantified liver/spleen attenuation ratio in patients with COVID-19. Conclusions: Some of the patients with COVID-19 displayed liver damage revealed by liver functional tests and upper abdominal CT imaging, and the severity of COVID-19 patients correlated with some of liver functional tests and CT signs; thus, it will allow an earlier identification of high-risk patients for early effective intervention.
KW - COVID-19
KW - Clinical profiles
KW - Liver
KW - Tomography
KW - X-ray computed
UR - http://www.scopus.com/inward/record.url?scp=85090302875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090302875&partnerID=8YFLogxK
U2 - 10.1007/s12072-020-10087-1
DO - 10.1007/s12072-020-10087-1
M3 - Article
C2 - 32886333
AN - SCOPUS:85090302875
VL - 14
SP - 733
EP - 742
JO - Hepatology International
JF - Hepatology International
SN - 1936-0533
IS - 5
ER -