Liver Disease in Patients on Total Parenteral Nutrition

Arnab Mitra, Joseph Ahn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Parenteral nutrition-associated liver disease (PNALD) spectrum ranges from liver enzyme abnormalities to steatosis to fibrosis, and, eventually, cirrhosis from total parenteral nutrition (TPN). The pathophysiology is postulated to be multifactorial. Diagnosis in adults is primarily by exclusion, eliminating other causes of chronic liver disease or cirrhosis, and other factors seen in critically ill or postoperative patients on TPN. Principal treatment is avoiding TPN. If this is not feasible, research supports fish oil-based lipid emulsions in TPN formulations to reduce risk and progression of PNALD. With liver and intestinal failure, liver and intestine transplant is an option.

Original languageEnglish (US)
JournalClinics in Liver Disease
DOIs
StateAccepted/In press - 2017

Fingerprint

Total Parenteral Nutrition
Liver Diseases
Parenteral Nutrition
Fibrosis
Fish Oils
Liver
Liver Failure
Emulsions
Critical Illness
Liver Cirrhosis
Intestines
Chronic Disease
Transplants
Lipids
Enzymes
Research
Therapeutics

Keywords

  • Cholestasis of sepsis
  • Combined intestinal and liver failure
  • PNALD
  • TPN

ASJC Scopus subject areas

  • Hepatology

Cite this

Liver Disease in Patients on Total Parenteral Nutrition. / Mitra, Arnab; Ahn, Joseph.

In: Clinics in Liver Disease, 2017.

Research output: Contribution to journalArticle

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