Live cell imaging of a fluorescent gentamicin conjugate

Jorge O. Escobedo, Yu Hsuan Chu, Qi Wang, Peter S. Steyger, Robert M. Strongin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Understanding cellular mechanisms of ototoxic and nephrotoxic drug uptake, intracellular distribution, and molecular trafficking across cellular barrier systems aids the study of potential uptake blockers that preserve sensory and renal function during critical life-saving therapy. Herein we report the design, synthesis characterization and evaluation of a fluorescent conjugate of the aminoglycoside antibiotic gentamicin. Live cell imaging results show the potential utility of this new material. Related gentamicin conjugates studied to date quench in live kindney cells, and have been largely restricted to use in fixed (delipidated) cells.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalNatural Product Communications
Volume7
Issue number3
StatePublished - 2012

Keywords

  • Aminoglycosides
  • Gentamicin
  • Ototoxic drugs

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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  • Cite this

    Escobedo, J. O., Chu, Y. H., Wang, Q., Steyger, P. S., & Strongin, R. M. (2012). Live cell imaging of a fluorescent gentamicin conjugate. Natural Product Communications, 7(3), 317-320.