Live and let die

Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

Sylvio Redanz, Xingqun Cheng, Rodrigo A. Giacaman, Carmem Pfeifer, Justin Merritt, Jens Kreth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H2O2 production is mainly dependent upon the pyruvate oxidase SpxB, and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H2O2 production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H2O2 generation, resistance mechanisms, and the ecological impact of H2O2 production. We also discuss the potential therapeutic utility of H2O2 for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.

Original languageEnglish (US)
JournalMolecular Oral Microbiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

lactate 2-monooxygenase
Microbiota
Hydrogen Peroxide
Pyruvate Oxidase
Oral Health
Biofilms
Streptococcus
Homeostasis
Biomarkers
Cell Membrane
Growth
Research
Therapeutics

Keywords

  • Biofilms
  • Hydrogen peroxide
  • Streptococci

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

Cite this

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abstract = "The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H2O2 production is mainly dependent upon the pyruvate oxidase SpxB, and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H2O2 production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H2O2 generation, resistance mechanisms, and the ecological impact of H2O2 production. We also discuss the potential therapeutic utility of H2O2 for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.",
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T2 - Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome

AU - Redanz, Sylvio

AU - Cheng, Xingqun

AU - Giacaman, Rodrigo A.

AU - Pfeifer, Carmem

AU - Merritt, Justin

AU - Kreth, Jens

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Y1 - 2018/1/1

N2 - The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H2O2 production is mainly dependent upon the pyruvate oxidase SpxB, and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H2O2 production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H2O2 generation, resistance mechanisms, and the ecological impact of H2O2 production. We also discuss the potential therapeutic utility of H2O2 for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.

AB - The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H2O2 production is mainly dependent upon the pyruvate oxidase SpxB, and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H2O2 production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H2O2 generation, resistance mechanisms, and the ecological impact of H2O2 production. We also discuss the potential therapeutic utility of H2O2 for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.

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KW - Hydrogen peroxide

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