Abstract
The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-505 |
| Number of pages | 9 |
| Journal | Archives of General Psychiatry |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health
Cite this
Lithium Ratio In Vitro : Diagnosis and Lithium Carbonate Response in Psychotic Patients. / Garver, David L.; Hitzemann, Robert; Hirschowitz, Jack.
In: Archives of General Psychiatry, Vol. 41, No. 5, 1984, p. 497-505.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lithium Ratio In Vitro
T2 - Diagnosis and Lithium Carbonate Response in Psychotic Patients
AU - Garver, David L.
AU - Hitzemann, Robert
AU - Hirschowitz, Jack
PY - 1984
Y1 - 1984
N2 - The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.
AB - The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.
UR - http://www.scopus.com/inward/record.url?scp=0021345686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021345686&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1984.01790160083011
DO - 10.1001/archpsyc.1984.01790160083011
M3 - Article
VL - 41
SP - 497
EP - 505
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 5
ER -