TY - JOUR
T1 - Lithium Ratio In Vitro
T2 - Diagnosis and Lithium Carbonate Response in Psychotic Patients
AU - Garver, David L.
AU - Hitzemann, Robert
AU - Hirschowitz, Jack
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1984/5
Y1 - 1984/5
N2 - The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.
AB - The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.
UR - http://www.scopus.com/inward/record.url?scp=0021345686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021345686&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1984.01790160083011
DO - 10.1001/archpsyc.1984.01790160083011
M3 - Article
C2 - 6426438
AN - SCOPUS:0021345686
SN - 0003-990X
VL - 41
SP - 497
EP - 505
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 5
ER -