Lithium Ratio In Vitro

Diagnosis and Lithium Carbonate Response in Psychotic Patients

David L. Garver, Robert Hitzemann, Jack Hirschowitz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The distribution of RBC lithium ratios in vitro in a recently hospitalized psychiatric population was found to be multimodal. Psychotic patients who had an antipsychotic response during open trials of lithium carbonate alone were identified with high sensitivity (89%), but low specificity (51%) before drug treatment, by lithium ratios that were in the extreme modes of the distribution (&0.30 or &0.38). Diagnostic efficiency of the test was 61%. The DSM-III diagnosis of schizophreniform disorder demonstrated 90% diagnostic efficiency in predicting response/nonresponse during treatment with lithium carbonate alone. A subgroup of the psychotic disorders was similar to affective disorders with respect to course of illness, biological characteristics, and response to lithium carbonate.

Original languageEnglish (US)
Pages (from-to)497-505
Number of pages9
JournalArchives of General Psychiatry
Volume41
Issue number5
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Lithium Carbonate
Lithium
Psychotic Disorders
Mood Disorders
Routine Diagnostic Tests
Diagnostic and Statistical Manual of Mental Disorders
Antipsychotic Agents
Psychiatry
Therapeutics
Pharmaceutical Preparations
Population
In Vitro Techniques
Carbonate
Diagnostics

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Lithium Ratio In Vitro : Diagnosis and Lithium Carbonate Response in Psychotic Patients. / Garver, David L.; Hitzemann, Robert; Hirschowitz, Jack.

In: Archives of General Psychiatry, Vol. 41, No. 5, 1984, p. 497-505.

Research output: Contribution to journalArticle

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