TY - JOUR
T1 - Lisuride treatment of focal dystonias
AU - Nutt, John G.
AU - Hammerstad, John P.
AU - Carter, Julie H.
AU - deGarmo, Patricia L.
PY - 1985/8
Y1 - 1985/8
N2 - Nine patients with various focal dystonias participated in a 12-week, double-blind, crossover comparison of the dopamine agonist, lisuride, and placebo. Lisuride produced mild objective and subjective improvement in six subjects, but the improvement was not sustained with continued therapy. Because the patients generally identified the active drug by side effects, biasing the study toward finding an effect, and because the benefits were mild and transient, we conclude that lisuride is of limited use in the treatment of focal dystonias.
AB - Nine patients with various focal dystonias participated in a 12-week, double-blind, crossover comparison of the dopamine agonist, lisuride, and placebo. Lisuride produced mild objective and subjective improvement in six subjects, but the improvement was not sustained with continued therapy. Because the patients generally identified the active drug by side effects, biasing the study toward finding an effect, and because the benefits were mild and transient, we conclude that lisuride is of limited use in the treatment of focal dystonias.
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U2 - 10.1212/wnl.35.8.1242
DO - 10.1212/wnl.35.8.1242
M3 - Article
C2 - 3895034
AN - SCOPUS:0021859338
SN - 0028-3878
VL - 35
SP - 1242
EP - 1243
JO - Neurology
JF - Neurology
IS - 8
ER -