Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

O. A. Odukoya; P. J. Houghton; A. Raman

doi:10.1016/S0944-7113(99)80017-8

Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

O. A. Odukoya, P. J. Houghton, A. Raman

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.

Original language	English (US)
Pages (from-to)	251-256
Number of pages	6
Journal	Phytomedicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/S0944-7113(99)80017-8
State	Published - Oct 1999
Externally published	Yes

Keywords

5-lipoxygenase inhibition
Aframomum danielli
Benzoquinones
Zingiberaceae

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1016/S0944-7113(99)80017-8

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title = "Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)",

abstract = "Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.",

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T1 - Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

AU - Odukoya, O. A.

AU - Houghton, P. J.

AU - Raman, A.

PY - 1999/10

Y1 - 1999/10

N2 - Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.

AB - Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.

KW - 5-lipoxygenase inhibition

KW - Aframomum danielli

KW - Benzoquinones

KW - Zingiberaceae

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ER -

Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

Abstract

Keywords

ASJC Scopus subject areas

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