Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

O. A. Odukoya, P. J. Houghton, Amala Soumyanath

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalPhytomedicine
Volume6
Issue number4
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Aframomum
Zingiberaceae
Arachidonate 5-Lipoxygenase
Lipoxygenase Inhibitors
benzoquinones
gasoline
lipoxygenase
Seed
Seeds
alcohols
Benzoquinones
Alcohols
Plastoquinone
seed extracts
extracts
seeds
anti-inflammatory activity
Anti-Inflammatory Agents
chemical derivatives
Derivatives

Keywords

  • 5-lipoxygenase inhibition
  • Aframomum danielli
  • Benzoquinones
  • Zingiberaceae

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae). / Odukoya, O. A.; Houghton, P. J.; Soumyanath, Amala.

In: Phytomedicine, Vol. 6, No. 4, 10.1999, p. 251-256.

Research output: Contribution to journalArticle

Odukoya, O. A. ; Houghton, P. J. ; Soumyanath, Amala. / Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae). In: Phytomedicine. 1999 ; Vol. 6, No. 4. pp. 251-256.
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