Lipoxygenase Inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae)

O. A. Odukoya, P. J. Houghton, A. Raman

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Alcohol and petrol extracts of the seeds of Aframomum danielli inhibit the soya 5-lipoxygenase enzyme and thus may show antiinflammatory activity. Compounds isolated from the active fractions were shown to be long chain polyprenyl benzoquinone derivatives. Phytylplastoquinone was isolated from the petrol extract and plastoquinone-7 (heptaplastoquinone) from the alcohol extract. The presence of these two known benzoquinones in A. danielli and their ability to inhibit 5-lipoxygenase are reported here for the first time.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalPhytomedicine
Volume6
Issue number4
DOIs
StatePublished - Oct 1999

Keywords

  • 5-lipoxygenase inhibition
  • Aframomum danielli
  • Benzoquinones
  • Zingiberaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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