Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus

Cecilia P. Chung, Annette Oeser, Paolo Raggi, Joseph F. Solus, Ingrid Avalos, MacRae F. Linton, Sergio Fazio, C. Michael Stein

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis, but the underlying mechanisms are unclear. The size and number of lipoprotein particles may be better predictors of atherosclerosis than conventional cholesterol measurements. We measured lipoprotein subclasses by nuclear magnetic resonance spectroscopy (NMR), coronary artery calcification by electron beam computed tomography, and insulin resistance by homeostasis model assessment in 105 patients with SLE and 77 control subjects. VLDL particles were larger (50.0 ± 8.5 versus 47.7 ± 8.5 nm, P = 0.01) and concentrations of large high-density lipoprotein (HDL) particles lower (10.1 ± 5.3 versus 11.3 ± 5.1 nmol/L, P = 0.03) in patients with SLE than controls. In patients with SLE, small LDL concentration was associated with body mass index (rho = 0.27), insulin resistance (rho = 0.34), C-reactive protein (CRP; rho = 0.30), and erythrocyte sedimentation rate (ESR; rho = 0.20); all P <0.05. Large HDL concentration was inversely associated with insulin resistance (rho = -0.29), disease activity (rho = -0.23), and ESR (rho = -0.39); all P <0.05. VLDL concentrations correlated with CRP (rho = 0.22), ESR (rho = 0.24), disease damage (rho = 0.20), and corticosteroid exposure (rho = 0.29); all P <0.05. Neither the concentration of lipoprotein subclasses nor particle size was associated with coronary artery atherosclerosis. There were only minor differences in the NMR lipid profiles of patients with SLE and controls. Lipoprotein subclasses were associated with metabolic variables, inflammatory markers, and corticosteroid use but not with coronary artery atherosclerosis in SLE.

Original languageEnglish (US)
Pages (from-to)1227-1233
Number of pages7
JournalClinical Rheumatology
Volume27
Issue number10
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Particle Size
Systemic Lupus Erythematosus
Lipoproteins
Magnetic Resonance Spectroscopy
Insulin Resistance
Coronary Vessels
HDL Lipoproteins
Coronary Artery Disease
Atherosclerosis
Adrenal Cortex Hormones
X Ray Computed Tomography
Blood Sedimentation
C-Reactive Protein
Body Mass Index
Homeostasis
Cholesterol
Lipids

Keywords

  • Atherosclerosis
  • Lipids
  • NMR
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Chung, C. P., Oeser, A., Raggi, P., Solus, J. F., Avalos, I., Linton, M. F., ... Michael Stein, C. (2008). Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. Clinical Rheumatology, 27(10), 1227-1233. https://doi.org/10.1007/s10067-008-0890-4

Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. / Chung, Cecilia P.; Oeser, Annette; Raggi, Paolo; Solus, Joseph F.; Avalos, Ingrid; Linton, MacRae F.; Fazio, Sergio; Michael Stein, C.

In: Clinical Rheumatology, Vol. 27, No. 10, 2008, p. 1227-1233.

Research output: Contribution to journalArticle

Chung, Cecilia P. ; Oeser, Annette ; Raggi, Paolo ; Solus, Joseph F. ; Avalos, Ingrid ; Linton, MacRae F. ; Fazio, Sergio ; Michael Stein, C. / Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. In: Clinical Rheumatology. 2008 ; Vol. 27, No. 10. pp. 1227-1233.
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AB - Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis, but the underlying mechanisms are unclear. The size and number of lipoprotein particles may be better predictors of atherosclerosis than conventional cholesterol measurements. We measured lipoprotein subclasses by nuclear magnetic resonance spectroscopy (NMR), coronary artery calcification by electron beam computed tomography, and insulin resistance by homeostasis model assessment in 105 patients with SLE and 77 control subjects. VLDL particles were larger (50.0 ± 8.5 versus 47.7 ± 8.5 nm, P = 0.01) and concentrations of large high-density lipoprotein (HDL) particles lower (10.1 ± 5.3 versus 11.3 ± 5.1 nmol/L, P = 0.03) in patients with SLE than controls. In patients with SLE, small LDL concentration was associated with body mass index (rho = 0.27), insulin resistance (rho = 0.34), C-reactive protein (CRP; rho = 0.30), and erythrocyte sedimentation rate (ESR; rho = 0.20); all P <0.05. Large HDL concentration was inversely associated with insulin resistance (rho = -0.29), disease activity (rho = -0.23), and ESR (rho = -0.39); all P <0.05. VLDL concentrations correlated with CRP (rho = 0.22), ESR (rho = 0.24), disease damage (rho = 0.20), and corticosteroid exposure (rho = 0.29); all P <0.05. Neither the concentration of lipoprotein subclasses nor particle size was associated with coronary artery atherosclerosis. There were only minor differences in the NMR lipid profiles of patients with SLE and controls. Lipoprotein subclasses were associated with metabolic variables, inflammatory markers, and corticosteroid use but not with coronary artery atherosclerosis in SLE.

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