Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus

Cecilia P. Chung, Annette Oeser, Paolo Raggi, Joseph F. Solus, Ingrid Avalos, MacRae F. Linton, Sergio Fazio, C. Michael Stein

    Research output: Contribution to journalArticle

    23 Scopus citations

    Abstract

    Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis, but the underlying mechanisms are unclear. The size and number of lipoprotein particles may be better predictors of atherosclerosis than conventional cholesterol measurements. We measured lipoprotein subclasses by nuclear magnetic resonance spectroscopy (NMR), coronary artery calcification by electron beam computed tomography, and insulin resistance by homeostasis model assessment in 105 patients with SLE and 77 control subjects. VLDL particles were larger (50.0 ± 8.5 versus 47.7 ± 8.5 nm, P = 0.01) and concentrations of large high-density lipoprotein (HDL) particles lower (10.1 ± 5.3 versus 11.3 ± 5.1 nmol/L, P = 0.03) in patients with SLE than controls. In patients with SLE, small LDL concentration was associated with body mass index (rho = 0.27), insulin resistance (rho = 0.34), C-reactive protein (CRP; rho = 0.30), and erythrocyte sedimentation rate (ESR; rho = 0.20); all P < 0.05. Large HDL concentration was inversely associated with insulin resistance (rho = -0.29), disease activity (rho = -0.23), and ESR (rho = -0.39); all P < 0.05. VLDL concentrations correlated with CRP (rho = 0.22), ESR (rho = 0.24), disease damage (rho = 0.20), and corticosteroid exposure (rho = 0.29); all P < 0.05. Neither the concentration of lipoprotein subclasses nor particle size was associated with coronary artery atherosclerosis. There were only minor differences in the NMR lipid profiles of patients with SLE and controls. Lipoprotein subclasses were associated with metabolic variables, inflammatory markers, and corticosteroid use but not with coronary artery atherosclerosis in SLE.

    Original languageEnglish (US)
    Pages (from-to)1227-1233
    Number of pages7
    JournalClinical Rheumatology
    Volume27
    Issue number10
    DOIs
    StatePublished - Apr 18 2008

    Keywords

    • Atherosclerosis
    • Lipids
    • NMR
    • Systemic lupus erythematosus

    ASJC Scopus subject areas

    • Rheumatology

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