Lipopolysaccharide Tolerance Inhibits Eye Inflammation: II. Preliminary Studies on the Mechanism

Edward L. Howes, James T. Rosenbaum

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalArchives of ophthalmology
Issue number2
StatePublished - Feb 1985
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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