TY - JOUR
T1 - Lipopolysaccharide Tolerance Inhibits Eye Inflammation
T2 - II. Preliminary Studies on the Mechanism
AU - Howes, Edward L.
AU - Rosenbaum, James T.
PY - 1985/2
Y1 - 1985/2
N2 - The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
AB - The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
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U2 - 10.1001/archopht.1985.01050020113032
DO - 10.1001/archopht.1985.01050020113032
M3 - Article
C2 - 3156579
AN - SCOPUS:0021933616
SN - 0003-9950
VL - 103
SP - 261
EP - 265
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 2
ER -