Abstract
The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-265 |
| Number of pages | 5 |
| Journal | Archives of Ophthalmology |
| Volume | 103 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Lipopolysaccharide Tolerance Inhibits Eye Inflammation : II. Preliminary Studies on the Mechanism. / Howes, Edward L.; Rosenbaum, James (Jim).
In: Archives of Ophthalmology, Vol. 103, No. 2, 1985, p. 261-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lipopolysaccharide Tolerance Inhibits Eye Inflammation
T2 - II. Preliminary Studies on the Mechanism
AU - Howes, Edward L.
AU - Rosenbaum, James (Jim)
PY - 1985
Y1 - 1985
N2 - The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
AB - The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
UR - http://www.scopus.com/inward/record.url?scp=0021933616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021933616&partnerID=8YFLogxK
U2 - 10.1001/archopht.1985.01050020113032
DO - 10.1001/archopht.1985.01050020113032
M3 - Article
C2 - 3156579
AN - SCOPUS:0021933616
VL - 103
SP - 261
EP - 265
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 2
ER -