Abstract
The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.
Original language | English (US) |
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Pages (from-to) | 261-265 |
Number of pages | 5 |
Journal | Archives of ophthalmology |
Volume | 103 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology