Lipopolysaccharide Tolerance Inhibits Eye Inflammation: I. Reduced Immune Complex or Lipopolysaccharide Effects

Edward L. Howes, Marc E. Goldyne, H. Daniel Perez, Ira M. Goldstein, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. A single intravenous (IV) injection of endotoxin (bacterial lipopolysaccharide [LPS]) produced a mild acute iridocyclitis. Repeated daily (five to seven days) IV injections of LPS (5 μg extracted from Salmonella typhimurium) led to a state of refractoriness or LPS “tolerance,” and ocular inflammation was no longer produced. In contrast to controls, in rabbits tolerant to LPS, IV LPS failed to elevate prostaglandin E2, thromboxane B2, or chemotactic factors in the aqueous humor. Rabbits tolerant to LPS also resisted the increase in vascular permeability normally induced by an ocular reversed passive Arthus reaction. These results demonstrated that LPS tolerance can induce anti-inflammatory effects in the eye.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalArchives of Ophthalmology
Volume103
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

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Antigen-Antibody Complex
Lipopolysaccharides
Inflammation
Rabbits
Endotoxins
Intravenous Injections
Arthus Reaction
Iridocyclitis
Thromboxane B2
Aqueous Humor
Chemotactic Factors
Capillary Permeability
Salmonella typhimurium
Dinoprostone
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lipopolysaccharide Tolerance Inhibits Eye Inflammation : I. Reduced Immune Complex or Lipopolysaccharide Effects. / Howes, Edward L.; Goldyne, Marc E.; Perez, H. Daniel; Goldstein, Ira M.; Rosenbaum, James (Jim).

In: Archives of Ophthalmology, Vol. 103, No. 2, 1985, p. 257-260.

Research output: Contribution to journalArticle

Howes, Edward L. ; Goldyne, Marc E. ; Perez, H. Daniel ; Goldstein, Ira M. ; Rosenbaum, James (Jim). / Lipopolysaccharide Tolerance Inhibits Eye Inflammation : I. Reduced Immune Complex or Lipopolysaccharide Effects. In: Archives of Ophthalmology. 1985 ; Vol. 103, No. 2. pp. 257-260.
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