Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy

Rebecca I. Spain, Nicole K. Andeen, Pamela C. Gibson, Mary H. Samuels, Cynthia D. Morris, Andrew J. Solomon, Richard Solomon, Carin Waslo, Rupali S. Avasare

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event specific to the treatment arm of our clinical trial investigating lipoic acid supplementation in patients with multiple sclerosis. This observation led to detection of similar patients in our nephrology practice. Here, we describe four biopsy-proven cases of neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy following lipoic acid supplementation and a fifth suspected case. Discontinuation of lipoic acid and supportive therapy resulted in remission.

Original languageEnglish (US)
Pages (from-to)1208-1213
Number of pages6
JournalKidney International
Volume100
Issue number6
DOIs
StatePublished - Dec 2021

Keywords

  • albuminuria
  • glomerulonephritis
  • kidney biopsy
  • kidney pathology
  • lipoic acid
  • membranous nephropathy
  • nephrotic syndrome
  • proteinuria

ASJC Scopus subject areas

  • Nephrology

Fingerprint

Dive into the research topics of 'Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy'. Together they form a unique fingerprint.

Cite this