Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

Priya Chaudhary, Gail Marracci, Danielle Galipeau, Edvinas Pocius, Brooke Morris, Dennis Bourdette

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalJournal of Neuroimmunology
Volume289
DOIs
Publication statusPublished - Dec 15 2015

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Keywords

  • Cortical lesions
  • Focal EAE
  • Immunofluorescence
  • Inflammation
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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