Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

Priya Chaudhary; Gail Marracci; Danielle Galipeau; Edvinas Pocius; Brooke Morris; Dennis Bourdette

doi:10.1016/j.jneuroim.2015.10.011

Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

Priya Chaudhary, Gail Marracci, Danielle Galipeau, Edvinas Pocius, Brooke Morris, Dennis Bourdette

Neurology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.

Original language	English (US)
Pages (from-to)	68-74
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	289
DOIs	https://doi.org/10.1016/j.jneuroim.2015.10.011
State	Published - Dec 15 2015

Keywords

Cortical lesions
Focal EAE
Immunofluorescence
Inflammation
Multiple sclerosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2015.10.011

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title = "Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model",

abstract = "Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.",

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author = "Priya Chaudhary and Gail Marracci and Danielle Galipeau and Edvinas Pocius and Brooke Morris and Dennis Bourdette",

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AU - Chaudhary, Priya

AU - Marracci, Gail

AU - Galipeau, Danielle

AU - Pocius, Edvinas

AU - Morris, Brooke

AU - Bourdette, Dennis

PY - 2015/12/15

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N2 - Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.

AB - Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4 + and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS.

KW - Cortical lesions

KW - Focal EAE

KW - Immunofluorescence

KW - Inflammation

KW - Multiple sclerosis

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Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

Abstract

Keywords

ASJC Scopus subject areas

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