Lipoic acid, inflammation and diseases of the nervous system

Daniel W. Carr, Sonemany Salinthone

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.

Original languageEnglish (US)
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Pages2349-2368
Number of pages20
ISBN (Electronic)9783642300189
ISBN (Print)3642300170, 9783642300172
DOIs
StatePublished - May 1 2012

Keywords

  • Diabetic neuropathy
  • Inflammation
  • Lipoic acid
  • Multiple sclerosis
  • Oxidative stress
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

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