Lipoic acid, inflammation and diseases of the nervous system

Daniel Carr, Sonemany Salinthone

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.

Original languageEnglish (US)
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Pages2349-2368
Number of pages20
ISBN (Print)9783642300189, 3642300170, 9783642300172
DOIs
StatePublished - May 1 2012

Fingerprint

Thioctic Acid
Nervous System Diseases
Inflammation
Biological Phenomena
Diabetic Neuropathies
Brain Ischemia
Multiple Sclerosis
Epilepsy
Oxidative Stress
Anti-Inflammatory Agents
Antioxidants
Stroke
Therapeutics

Keywords

  • Diabetic neuropathy
  • Inflammation
  • Lipoic acid
  • Multiple sclerosis
  • Oxidative stress
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Carr, D., & Salinthone, S. (2012). Lipoic acid, inflammation and diseases of the nervous system. In Systems Biology of Free Radicals and Antioxidants (pp. 2349-2368). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_86

Lipoic acid, inflammation and diseases of the nervous system. / Carr, Daniel; Salinthone, Sonemany.

Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, 2012. p. 2349-2368.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carr, D & Salinthone, S 2012, Lipoic acid, inflammation and diseases of the nervous system. in Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, pp. 2349-2368. https://doi.org/10.1007/978-3-642-30018-9_86
Carr D, Salinthone S. Lipoic acid, inflammation and diseases of the nervous system. In Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg. 2012. p. 2349-2368 https://doi.org/10.1007/978-3-642-30018-9_86
Carr, Daniel ; Salinthone, Sonemany. / Lipoic acid, inflammation and diseases of the nervous system. Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, 2012. pp. 2349-2368
@inbook{2b6b70f20eb64b93b27ecb36d508a411,
title = "Lipoic acid, inflammation and diseases of the nervous system",
abstract = "Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.",
keywords = "Diabetic neuropathy, Inflammation, Lipoic acid, Multiple sclerosis, Oxidative stress, Stroke",
author = "Daniel Carr and Sonemany Salinthone",
year = "2012",
month = "5",
day = "1",
doi = "10.1007/978-3-642-30018-9_86",
language = "English (US)",
isbn = "9783642300189",
pages = "2349--2368",
booktitle = "Systems Biology of Free Radicals and Antioxidants",
publisher = "Springer-Verlag Berlin Heidelberg",

}

TY - CHAP

T1 - Lipoic acid, inflammation and diseases of the nervous system

AU - Carr, Daniel

AU - Salinthone, Sonemany

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.

AB - Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.

KW - Diabetic neuropathy

KW - Inflammation

KW - Lipoic acid

KW - Multiple sclerosis

KW - Oxidative stress

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=84929138322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929138322&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-30018-9_86

DO - 10.1007/978-3-642-30018-9_86

M3 - Chapter

AN - SCOPUS:84929138322

SN - 9783642300189

SN - 3642300170

SN - 9783642300172

SP - 2349

EP - 2368

BT - Systems Biology of Free Radicals and Antioxidants

PB - Springer-Verlag Berlin Heidelberg

ER -