Oxidative stress and inflammation are normal biological processes that are implicated in the pathogenesis of many neurological diseases such as multiple sclerosis, cerebral ischemia, stroke, epilepsy, and diabetic neuropathy. Treatment with compounds that can block these processes has the potential to be therapeutically effective. Lipoic acid is a naturally occurring supplement that appears to act both as an antioxidant and an anti-inflammatory agent. This chapter reviews the current data on the effectiveness of LA for each of the above-mentioned diseases and also examines the possible mechanisms of actions that allow LA to function as a therapeutic agent.
|Original language||English (US)|
|Title of host publication||Systems Biology of Free Radicals and Antioxidants|
|Publisher||Springer-Verlag Berlin Heidelberg|
|Number of pages||20|
|ISBN (Print)||9783642300189, 3642300170, 9783642300172|
|Publication status||Published - May 1 2012|
- Diabetic neuropathy
- Lipoic acid
- Multiple sclerosis
- Oxidative stress
ASJC Scopus subject areas
Lipoic acid, inflammation and diseases of the nervous system. / Carr, Daniel; Salinthone, Sonemany.Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, 2012. p. 2349-2368.
Research output: Chapter in Book/Report/Conference proceeding › Chapter