Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy

K. A. Bybee, Jr O'Keefe J.H., William Harris, S. Garg, S. J. George, T. M. Bateman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Patients with known coronary artery disease frequently change their lifestyles (e.g., diet, exercise, and smoking habit) after the diagnosis is made. Such changes can alter lipid risk factor levels and obscure etiologic risk factor associations with the presence of coronary artery disease. It is therefore preferable to determine the contribution of potential risk factors before the diagnosis of coronary artery disease has been established. In this trial, we used stress nuclear myocardial perfusion imaging to diagnose coronary artery disease in patients presenting for evaluation of chest pain. Two groups of age- and sex-matched patients were identified: a normal group (patients with no evidence of coronary artery disease), and an abnormal group (patients whose scans indicated the presence of significant coronary artery disease due to either fixed or reversible perfusion defects). Blood samples were drawn before scanning and analyzed for lipid risk factors. Compared to the normal group, the abnormal group had higher levels of triglycerides (189±91 vs. 135±51 mg/dL, p=0.003), lower levels of high density lipoprotein cholesterol (39±9 vs. 45±14 mg/dL, p=0.037), and higher levels of small, dense low density lipoprotein (LDL3) (42±18 vs. 32±13 mg/dL, p=0.007). Total cholesterol, low density lipoprotein, and lipoprotein(a) levels were similar between groups. These findings suggest that ischemic heart disease, as assessed by myocardial perfusion scintigrapby, is more closely associated with the low high density lipoprotein/high triglyceride syndrome than with increased low density lipoprotein or total cholesterol levels. (C) 2000 by CHF, Inc.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalPreventive Cardiology
Volume3
Issue number4
StatePublished - 2000
Externally publishedYes

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Myocardial Perfusion Imaging
Perfusion Imaging
Myocardial Ischemia
Coronary Artery Disease
Lipids
LDL Lipoproteins
Triglycerides
Perfusion
Lipoprotein(a)
HDL Lipoproteins
Chest Pain
LDL Cholesterol
HDL Cholesterol
Habits
Life Style
Age Groups
Smoking
Cholesterol
Exercise
Diet

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health

Cite this

Bybee, K. A., O'Keefe J.H., J., Harris, W., Garg, S., George, S. J., & Bateman, T. M. (2000). Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy. Preventive Cardiology, 3(4), 154-159.

Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy. / Bybee, K. A.; O'Keefe J.H., Jr; Harris, William; Garg, S.; George, S. J.; Bateman, T. M.

In: Preventive Cardiology, Vol. 3, No. 4, 2000, p. 154-159.

Research output: Contribution to journalArticle

Bybee, KA, O'Keefe J.H., J, Harris, W, Garg, S, George, SJ & Bateman, TM 2000, 'Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy', Preventive Cardiology, vol. 3, no. 4, pp. 154-159.
Bybee KA, O'Keefe J.H. J, Harris W, Garg S, George SJ, Bateman TM. Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy. Preventive Cardiology. 2000;3(4):154-159.
Bybee, K. A. ; O'Keefe J.H., Jr ; Harris, William ; Garg, S. ; George, S. J. ; Bateman, T. M. / Lipid risk factor correlates of ischemic heart disease as diagnosed by myocardial perfusion scintigraphy. In: Preventive Cardiology. 2000 ; Vol. 3, No. 4. pp. 154-159.
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