Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study

I. R. Gizer, C. L. Ehlers, C. Vieten, K. L. Seaton-Smith, Heidi Feiler, J. V. Lee, S. K. Segall, D. A. Gilder, K. C. Wilhelmsen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Nicotine dependence has been shown to represent a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder though only a limited number of the findings have been replicated.Method In the present study, a genome-wide linkage scan for nicotine dependence was conducted in a community sample of 950 probands and 1204 relatives recruited through the University of California, San Francisco (UCSF) Family Alcoholism Study. A modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) with additional questions that probe nicotine use was used to derive DSM-IV nicotine dependence diagnoses.Results A locus on chromosome 2q31.1 at 184 centiMorgans nearest to marker D2S2188 yielded a logarithm (base 10) of odds (LOD) score of 3.54 (point-wise empirical p=0.000012). Additional peaks of interest were identified on chromosomes 2q13, 4p15.33-31, 11q25 and 12p11.23-21. Follow-up analyses were conducted examining the contributions of individual nicotine dependence symptoms to the chromosome 2q31.1 linkage peak as well as examining the relationship of this chromosomal region to alcohol dependence.Conclusions The present report suggests that chromosome 2q31.1 confers risk to the development of nicotine dependence and that this region influences a broad range of nicotine dependence symptoms rather than a specific facet of the disorder. Further, the results show that this region is not linked to alcohol dependence in this population, and thus may influence nicotine dependence specifically.

Original languageEnglish (US)
Pages (from-to)799-808
Number of pages10
JournalPsychological Medicine
Volume41
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Tobacco Use Disorder
San Francisco
Alcoholism
Chromosomes
Nicotine
Diagnostic and Statistical Manual of Mental Disorders
Genome
Research
Population

Keywords

  • Genetics
  • genome scan
  • linkage
  • nicotine dependence
  • smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology

Cite this

Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study. / Gizer, I. R.; Ehlers, C. L.; Vieten, C.; Seaton-Smith, K. L.; Feiler, Heidi; Lee, J. V.; Segall, S. K.; Gilder, D. A.; Wilhelmsen, K. C.

In: Psychological Medicine, Vol. 41, No. 4, 04.2011, p. 799-808.

Research output: Contribution to journalArticle

Gizer, IR, Ehlers, CL, Vieten, C, Seaton-Smith, KL, Feiler, H, Lee, JV, Segall, SK, Gilder, DA & Wilhelmsen, KC 2011, 'Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study', Psychological Medicine, vol. 41, no. 4, pp. 799-808. https://doi.org/10.1017/S0033291710001273
Gizer, I. R. ; Ehlers, C. L. ; Vieten, C. ; Seaton-Smith, K. L. ; Feiler, Heidi ; Lee, J. V. ; Segall, S. K. ; Gilder, D. A. ; Wilhelmsen, K. C. / Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study. In: Psychological Medicine. 2011 ; Vol. 41, No. 4. pp. 799-808.
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AU - Seaton-Smith, K. L.

AU - Feiler, Heidi

AU - Lee, J. V.

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N2 - Background Nicotine dependence has been shown to represent a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder though only a limited number of the findings have been replicated.Method In the present study, a genome-wide linkage scan for nicotine dependence was conducted in a community sample of 950 probands and 1204 relatives recruited through the University of California, San Francisco (UCSF) Family Alcoholism Study. A modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) with additional questions that probe nicotine use was used to derive DSM-IV nicotine dependence diagnoses.Results A locus on chromosome 2q31.1 at 184 centiMorgans nearest to marker D2S2188 yielded a logarithm (base 10) of odds (LOD) score of 3.54 (point-wise empirical p=0.000012). Additional peaks of interest were identified on chromosomes 2q13, 4p15.33-31, 11q25 and 12p11.23-21. Follow-up analyses were conducted examining the contributions of individual nicotine dependence symptoms to the chromosome 2q31.1 linkage peak as well as examining the relationship of this chromosomal region to alcohol dependence.Conclusions The present report suggests that chromosome 2q31.1 confers risk to the development of nicotine dependence and that this region influences a broad range of nicotine dependence symptoms rather than a specific facet of the disorder. Further, the results show that this region is not linked to alcohol dependence in this population, and thus may influence nicotine dependence specifically.

AB - Background Nicotine dependence has been shown to represent a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder though only a limited number of the findings have been replicated.Method In the present study, a genome-wide linkage scan for nicotine dependence was conducted in a community sample of 950 probands and 1204 relatives recruited through the University of California, San Francisco (UCSF) Family Alcoholism Study. A modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) with additional questions that probe nicotine use was used to derive DSM-IV nicotine dependence diagnoses.Results A locus on chromosome 2q31.1 at 184 centiMorgans nearest to marker D2S2188 yielded a logarithm (base 10) of odds (LOD) score of 3.54 (point-wise empirical p=0.000012). Additional peaks of interest were identified on chromosomes 2q13, 4p15.33-31, 11q25 and 12p11.23-21. Follow-up analyses were conducted examining the contributions of individual nicotine dependence symptoms to the chromosome 2q31.1 linkage peak as well as examining the relationship of this chromosomal region to alcohol dependence.Conclusions The present report suggests that chromosome 2q31.1 confers risk to the development of nicotine dependence and that this region influences a broad range of nicotine dependence symptoms rather than a specific facet of the disorder. Further, the results show that this region is not linked to alcohol dependence in this population, and thus may influence nicotine dependence specifically.

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