Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM

Joel Gelernter; A. J. Pakstis; D. Grandy; M. Lilt; A. E. Relief; J. L. Kennedy; A. Hing-Loh; G. Schoolfield; O. Civelli; K. K. Kidd

doi:10.1159/000133287

Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM

Joel Gelernter, A. J. Pakstis, D. Grandy, M. Lilt, A. E. Relief, J. L. Kennedy, A. Hing-Loh, G. Schoolfield, O. Civelli, K. K. Kidd

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4 Scopus citations

Abstract

We have constructed a linkage map of eight RFLP markers located on chromosome 11q in the region of the dopamine D2 receptor gene (DRD2) recognized by probe hD2G1. Abnormalities in dopaminergic neurotransmission mediated by this receptor have been implicated in several psychiatric disorders. The map was generated using six large reference families (from 294 to 419 individuals per locus), which are largely independent of the CEPH families, primarily using the LINKMAP and ILINK programs of the LINKAGE package of Lathrop and Lalouel. The most likely order and recombination frequencies are: cen-D11S146-INT2-DllS36-(DllS84, STMY)-DRD2-DllS29-PBGD-qter 0.001 0.213 0.123 0.001 0.158 0.035 0.093 The relative order of D11S84-STMY, DRD2-D11S29, and D1IS146-INT2 could not be resolved reliably. There were no significant sex differences in recombination frequency. We introduce here a version of LINKMAP adapted to run under distributed parallel processing (LINDA-LINKMAP). Using pairwise analyses, we have also placed D11S421 proximal to this group.

Original language	English (US)
Pages (from-to)	26-28
Number of pages	3
Journal	Cytogenetics and Cell Genetics
Volume	60
Issue number	1
DOIs	https://doi.org/10.1159/000133287
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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@article{1c029f718679413daae218fd9cb4c0d2,

title = "Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM",

abstract = "We have constructed a linkage map of eight RFLP markers located on chromosome 11q in the region of the dopamine D2 receptor gene (DRD2) recognized by probe hD2G1. Abnormalities in dopaminergic neurotransmission mediated by this receptor have been implicated in several psychiatric disorders. The map was generated using six large reference families (from 294 to 419 individuals per locus), which are largely independent of the CEPH families, primarily using the LINKMAP and ILINK programs of the LINKAGE package of Lathrop and Lalouel. The most likely order and recombination frequencies are: cen-D11S146-INT2-DllS36-(DllS84, STMY)-DRD2-DllS29-PBGD-qter 0.001 0.213 0.123 0.001 0.158 0.035 0.093 The relative order of D11S84-STMY, DRD2-D11S29, and D1IS146-INT2 could not be resolved reliably. There were no significant sex differences in recombination frequency. We introduce here a version of LINKMAP adapted to run under distributed parallel processing (LINDA-LINKMAP). Using pairwise analyses, we have also placed D11S421 proximal to this group.",

author = "Joel Gelernter and Pakstis, {A. J.} and D. Grandy and M. Lilt and Relief, {A. E.} and Kennedy, {J. L.} and A. Hing-Loh and G. Schoolfield and O. Civelli and Kidd, {K. K.}",

year = "1992",

doi = "10.1159/000133287",

language = "English (US)",

volume = "60",

pages = "26--28",

journal = "Cytogenetic and Genome Research",

issn = "1424-8581",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM

AU - Gelernter, Joel

AU - Pakstis, A. J.

AU - Grandy, D.

AU - Lilt, M.

AU - Relief, A. E.

AU - Kennedy, J. L.

AU - Hing-Loh, A.

AU - Schoolfield, G.

AU - Civelli, O.

AU - Kidd, K. K.

PY - 1992

Y1 - 1992

N2 - We have constructed a linkage map of eight RFLP markers located on chromosome 11q in the region of the dopamine D2 receptor gene (DRD2) recognized by probe hD2G1. Abnormalities in dopaminergic neurotransmission mediated by this receptor have been implicated in several psychiatric disorders. The map was generated using six large reference families (from 294 to 419 individuals per locus), which are largely independent of the CEPH families, primarily using the LINKMAP and ILINK programs of the LINKAGE package of Lathrop and Lalouel. The most likely order and recombination frequencies are: cen-D11S146-INT2-DllS36-(DllS84, STMY)-DRD2-DllS29-PBGD-qter 0.001 0.213 0.123 0.001 0.158 0.035 0.093 The relative order of D11S84-STMY, DRD2-D11S29, and D1IS146-INT2 could not be resolved reliably. There were no significant sex differences in recombination frequency. We introduce here a version of LINKMAP adapted to run under distributed parallel processing (LINDA-LINKMAP). Using pairwise analyses, we have also placed D11S421 proximal to this group.

AB - We have constructed a linkage map of eight RFLP markers located on chromosome 11q in the region of the dopamine D2 receptor gene (DRD2) recognized by probe hD2G1. Abnormalities in dopaminergic neurotransmission mediated by this receptor have been implicated in several psychiatric disorders. The map was generated using six large reference families (from 294 to 419 individuals per locus), which are largely independent of the CEPH families, primarily using the LINKMAP and ILINK programs of the LINKAGE package of Lathrop and Lalouel. The most likely order and recombination frequencies are: cen-D11S146-INT2-DllS36-(DllS84, STMY)-DRD2-DllS29-PBGD-qter 0.001 0.213 0.123 0.001 0.158 0.035 0.093 The relative order of D11S84-STMY, DRD2-D11S29, and D1IS146-INT2 could not be resolved reliably. There were no significant sex differences in recombination frequency. We introduce here a version of LINKMAP adapted to run under distributed parallel processing (LINDA-LINKMAP). Using pairwise analyses, we have also placed D11S421 proximal to this group.

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JO - Cytogenetic and Genome Research

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Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM

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