Linear relationship between plasma concentration and dosage of sodium valproate

John Nutt, H. J. Kupferberg

Research output: Contribution to journalArticle

9 Scopus citations


Plasma valproate concentration was studied in 7 hospitalized nonepileptic patients who received sodium valproate at daily doses of up to 60 mg/kg. A linear relationship between dose and plasma concentration of valproate (r = 0.81-0.99) was found in each patient, although the slopes of the regression lines (reflecting clearance rates) varied twofold. This suggests that if the valproate plasma concentrations at 2 different doses are known and the clearance of valproate is not altered by concomitant administration of other drugs, it should be possible to predict the plasma valproate concentration that will result from further dose increments.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
Issue number6
Publication statusPublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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