Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis

Preliminary results

Joshua Nickerson, Christopher J. Koski, Andrew C. Boyer, Heather N. Burbank, Rup Tandan, Christopher G. Filippi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Purpose: : As potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. Patients and Methods: : Two patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls. Results: : Both patients showed linear decreases in FA values over time with R2 values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps. Conclusion: : If these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalClinical Neuroradiology
Volume19
Issue number2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Anisotropy
Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Diffusion Tensor Imaging
Motor Neurons
Nerve Degeneration
Pyramidal Tracts
Disease Progression
Biomarkers

Keywords

  • Amyotrophic lateral sclerosis
  • Diffusion tensor imaging
  • Fractional anisotropy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis : Preliminary results. / Nickerson, Joshua; Koski, Christopher J.; Boyer, Andrew C.; Burbank, Heather N.; Tandan, Rup; Filippi, Christopher G.

In: Clinical Neuroradiology, Vol. 19, No. 2, 01.06.2009, p. 129-134.

Research output: Contribution to journalArticle

Nickerson, Joshua ; Koski, Christopher J. ; Boyer, Andrew C. ; Burbank, Heather N. ; Tandan, Rup ; Filippi, Christopher G. / Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis : Preliminary results. In: Clinical Neuroradiology. 2009 ; Vol. 19, No. 2. pp. 129-134.
@article{fd746fcfb09a409aa691efb0ca580e5f,
title = "Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis: Preliminary results",
abstract = "Background and Purpose: : As potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. Patients and Methods: : Two patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls. Results: : Both patients showed linear decreases in FA values over time with R2 values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps. Conclusion: : If these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease.",
keywords = "Amyotrophic lateral sclerosis, Diffusion tensor imaging, Fractional anisotropy",
author = "Joshua Nickerson and Koski, {Christopher J.} and Boyer, {Andrew C.} and Burbank, {Heather N.} and Rup Tandan and Filippi, {Christopher G.}",
year = "2009",
month = "6",
day = "1",
doi = "10.1007/s00062-009-8040-1",
language = "English (US)",
volume = "19",
pages = "129--134",
journal = "Clinical Neuroradiology",
issn = "1869-1439",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis

T2 - Preliminary results

AU - Nickerson, Joshua

AU - Koski, Christopher J.

AU - Boyer, Andrew C.

AU - Burbank, Heather N.

AU - Tandan, Rup

AU - Filippi, Christopher G.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Background and Purpose: : As potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. Patients and Methods: : Two patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls. Results: : Both patients showed linear decreases in FA values over time with R2 values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps. Conclusion: : If these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease.

AB - Background and Purpose: : As potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. Patients and Methods: : Two patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls. Results: : Both patients showed linear decreases in FA values over time with R2 values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps. Conclusion: : If these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease.

KW - Amyotrophic lateral sclerosis

KW - Diffusion tensor imaging

KW - Fractional anisotropy

UR - http://www.scopus.com/inward/record.url?scp=67349116009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349116009&partnerID=8YFLogxK

U2 - 10.1007/s00062-009-8040-1

DO - 10.1007/s00062-009-8040-1

M3 - Article

VL - 19

SP - 129

EP - 134

JO - Clinical Neuroradiology

JF - Clinical Neuroradiology

SN - 1869-1439

IS - 2

ER -