Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy

Christopher J. Kane, Christopher Amling, Peter A S Johnstone, Nali Pak, Raymond S. Lance, J. Brantley Thrasher, John P. Foley, Robert H. Riffenburgh, Judd W. Moul

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Objectives: To define the utility of bone scan and computed tomography (CT) in the evaluation of patients with biochemical recurrence after radical prostatectomy. Methods: A retrospective analysis of the Center for Prostate Disease Research database was undertaken to identify patients who underwent radical prostatectomy between 1989 and 1998. Patients who developed biochemical recurrence (two prostate-specific antigen [PSA] levels greater than 0.2 ng/mL) and underwent either bone scan or CT within 3 years of this recurrence were selected for analysis. The preoperative clinical parameters, pathologic findings, serum PSA levels, follow-up data, and radiographic results were reviewed. Results: One hundred thirty-two patients with biochemical recurrence and a bone scan or CT scan were identified. Of the 127 bone scans, 12 (9.4%) were positive. The patients with true-positive bone scans had an average PSA at the time of the bone scan of 61.3 ± 71.2 ng/mL (range 1.3 to 123). Their PSA velocities, calculated from the PSA levels determined immediately before the radiographic studies, averaged 22.1 ± 24.7 ng/mL/mo (range 0.14 to 60.0). Only 2 patients with a positive bone scan had a PSA velocity of less than 0.5 ng/mL/mo. Of the 86 CT scans, 12 (14.0%) were positive. On logistic regression analysis, PSA and PSA velocity predicted the bone scan result (P

Original languageEnglish (US)
Pages (from-to)607-611
Number of pages5
JournalUrology
Volume61
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Prostate-Specific Antigen
Prostatectomy
Radionuclide Imaging
Tomography
Bone and Bones
Recurrence
Prostate
Logistic Models
Regression Analysis
Databases
Serum
Research

ASJC Scopus subject areas

  • Urology

Cite this

Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. / Kane, Christopher J.; Amling, Christopher; Johnstone, Peter A S; Pak, Nali; Lance, Raymond S.; Thrasher, J. Brantley; Foley, John P.; Riffenburgh, Robert H.; Moul, Judd W.

In: Urology, Vol. 61, No. 3, 01.03.2003, p. 607-611.

Research output: Contribution to journalArticle

Kane, CJ, Amling, C, Johnstone, PAS, Pak, N, Lance, RS, Thrasher, JB, Foley, JP, Riffenburgh, RH & Moul, JW 2003, 'Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy', Urology, vol. 61, no. 3, pp. 607-611. https://doi.org/10.1016/S0090-4295(02)02411-1
Kane, Christopher J. ; Amling, Christopher ; Johnstone, Peter A S ; Pak, Nali ; Lance, Raymond S. ; Thrasher, J. Brantley ; Foley, John P. ; Riffenburgh, Robert H. ; Moul, Judd W. / Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. In: Urology. 2003 ; Vol. 61, No. 3. pp. 607-611.
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