Light stimulation of iris tyrosinase r487w7 =eyes in vivo

T. P. Dryja, G. P. Kimball, Daniel Albert

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although exposure of epidermal melanocytes to ultraviolet radiation is known to increase tyrosinase activity, a similar effect has never been demonstrated for the iris. This paper presents evidence that light stimulates tyrosinase activity in iris melanocytes in rabbits. Levels of iris tyrosinase were found to be greater in eyes of rabbits exposed to light for 6 weeks than in eye of rabbits maintained in darkness. Despite increasing tyrosinase levels, exposure to light produced no clinically observable change in iris color.

Original languageEnglish (US)
Pages (from-to)559-562
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number5
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Monophenol Monooxygenase
Iris
Light
Melanocytes
Rabbits
Darkness
Color
Radiation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Light stimulation of iris tyrosinase r487w7 =eyes in vivo. / Dryja, T. P.; Kimball, G. P.; Albert, Daniel.

In: Investigative Ophthalmology and Visual Science, Vol. 19, No. 5, 01.12.1980, p. 559-562.

Research output: Contribution to journalArticle

@article{fda61c265056490cbbfe24a2cb5347ff,
title = "Light stimulation of iris tyrosinase r487w7 =eyes in vivo",
abstract = "Although exposure of epidermal melanocytes to ultraviolet radiation is known to increase tyrosinase activity, a similar effect has never been demonstrated for the iris. This paper presents evidence that light stimulates tyrosinase activity in iris melanocytes in rabbits. Levels of iris tyrosinase were found to be greater in eyes of rabbits exposed to light for 6 weeks than in eye of rabbits maintained in darkness. Despite increasing tyrosinase levels, exposure to light produced no clinically observable change in iris color.",
author = "Dryja, {T. P.} and Kimball, {G. P.} and Daniel Albert",
year = "1980",
month = "12",
day = "1",
language = "English (US)",
volume = "19",
pages = "559--562",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "5",

}

TY - JOUR

T1 - Light stimulation of iris tyrosinase r487w7 =eyes in vivo

AU - Dryja, T. P.

AU - Kimball, G. P.

AU - Albert, Daniel

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Although exposure of epidermal melanocytes to ultraviolet radiation is known to increase tyrosinase activity, a similar effect has never been demonstrated for the iris. This paper presents evidence that light stimulates tyrosinase activity in iris melanocytes in rabbits. Levels of iris tyrosinase were found to be greater in eyes of rabbits exposed to light for 6 weeks than in eye of rabbits maintained in darkness. Despite increasing tyrosinase levels, exposure to light produced no clinically observable change in iris color.

AB - Although exposure of epidermal melanocytes to ultraviolet radiation is known to increase tyrosinase activity, a similar effect has never been demonstrated for the iris. This paper presents evidence that light stimulates tyrosinase activity in iris melanocytes in rabbits. Levels of iris tyrosinase were found to be greater in eyes of rabbits exposed to light for 6 weeks than in eye of rabbits maintained in darkness. Despite increasing tyrosinase levels, exposure to light produced no clinically observable change in iris color.

UR - http://www.scopus.com/inward/record.url?scp=0019292340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019292340&partnerID=8YFLogxK

M3 - Article

C2 - 6768692

AN - SCOPUS:0019292340

VL - 19

SP - 559

EP - 562

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 5

ER -