Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

Karl Obrietan; Soren Impey; Daniel R. Storm

doi:10.1038/3695

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

Karl Obrietan, Soren Impey, Daniel R. Storm

Research output: Contribution to journal › Article › peer-review

324 Scopus citations

Abstract

Although the circadian time-keeping properties of the suprachiasmatic nuclei (SCN) require gene expression, little is known about the signal transduction pathways that initiate transcription. Here we report that a brief exposure to light during the subjective night, but not during the subjective day, activates the p44/42 mitogen-activated protein kinase (MAPK) signaling cascade in the SCN. In addition, MAPK stimulation activates CREB (cAMP response element binding protein), indicating that potential downstream transcription factors are stimulated by the MAPK pathway in the SCN. We also observed striking circadian variations in MAPK activity within the SCN, suggesting that the MAPK cascade is involved in clock rhythmicity.

Original language	English (US)
Pages (from-to)	693-700
Number of pages	8
Journal	Nature Neuroscience
Volume	1
Issue number	8
DOIs	https://doi.org/10.1038/3695
State	Published - Dec 1998
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei",

abstract = "Although the circadian time-keeping properties of the suprachiasmatic nuclei (SCN) require gene expression, little is known about the signal transduction pathways that initiate transcription. Here we report that a brief exposure to light during the subjective night, but not during the subjective day, activates the p44/42 mitogen-activated protein kinase (MAPK) signaling cascade in the SCN. In addition, MAPK stimulation activates CREB (cAMP response element binding protein), indicating that potential downstream transcription factors are stimulated by the MAPK pathway in the SCN. We also observed striking circadian variations in MAPK activity within the SCN, suggesting that the MAPK cascade is involved in clock rhythmicity.",

author = "Karl Obrietan and Soren Impey and Storm, {Daniel R.}",

note = "Funding Information: We thank S. Poser and J. Athos for comments on the manuscript. Confocal microscopy and image analysis was done in the W. M. Keck Center for Neural Signaling, University of Washington. This research was supported by National Institutes of Health grant NS 20498.",

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AU - Impey, Soren

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N2 - Although the circadian time-keeping properties of the suprachiasmatic nuclei (SCN) require gene expression, little is known about the signal transduction pathways that initiate transcription. Here we report that a brief exposure to light during the subjective night, but not during the subjective day, activates the p44/42 mitogen-activated protein kinase (MAPK) signaling cascade in the SCN. In addition, MAPK stimulation activates CREB (cAMP response element binding protein), indicating that potential downstream transcription factors are stimulated by the MAPK pathway in the SCN. We also observed striking circadian variations in MAPK activity within the SCN, suggesting that the MAPK cascade is involved in clock rhythmicity.

AB - Although the circadian time-keeping properties of the suprachiasmatic nuclei (SCN) require gene expression, little is known about the signal transduction pathways that initiate transcription. Here we report that a brief exposure to light during the subjective night, but not during the subjective day, activates the p44/42 mitogen-activated protein kinase (MAPK) signaling cascade in the SCN. In addition, MAPK stimulation activates CREB (cAMP response element binding protein), indicating that potential downstream transcription factors are stimulated by the MAPK pathway in the SCN. We also observed striking circadian variations in MAPK activity within the SCN, suggesting that the MAPK cascade is involved in clock rhythmicity.

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Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

Abstract

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