Levonorgestrel-releasing intrauterine system for heavy menstrual bleeding improves hemoglobin and ferritin levels

Andrew M. Kaunitz, François Bissonnette, Ilza Monteiro, Eeva Lukkari-Lax, Yoriko Desanctis, Jeffrey Jensen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: We compared the effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) with cyclic oral medroxyprogesterone acetate (MPA) on hemoglobin and serum ferritin levels in women with heavy menstrual bleeding (HMB). Study Design: This was a multicenter, randomized study assessing the efficacy of the LNG-IUS and oral MPA (10 mg/day for 10 days) in women with confirmed HMB over 6 cycles of treatment. We previously reported that treatment with the LNG-IUS resulted in greater menstrual blood loss reduction than MPA. In this analysis, hemoglobin and serum ferritin levels were assessed at baseline, Cycle 3, and at Cycle 6, and the relative improvement on treatment was subjectively rated by investigators and women. Results: One hundred and sixty-five women were randomized (82 LNG-IUS/83 MPA). Increases in median hemoglobin levels from baseline to Cycle 6 (7.5% vs. 1.9%; p

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalContraception
Volume86
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Levonorgestrel
Medroxyprogesterone Acetate
Ferritins
Hemoglobins
Hemorrhage
Serum
Multicenter Studies
Therapeutics
Research Personnel

Keywords

  • Ferritin
  • Hemoglobin
  • Levonorgestrel-releasing intrauterine system
  • Medroxyprogesterone acetate
  • Menorrhagia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Levonorgestrel-releasing intrauterine system for heavy menstrual bleeding improves hemoglobin and ferritin levels. / Kaunitz, Andrew M.; Bissonnette, François; Monteiro, Ilza; Lukkari-Lax, Eeva; Desanctis, Yoriko; Jensen, Jeffrey.

In: Contraception, Vol. 86, No. 5, 11.2012, p. 452-457.

Research output: Contribution to journalArticle

Kaunitz, Andrew M. ; Bissonnette, François ; Monteiro, Ilza ; Lukkari-Lax, Eeva ; Desanctis, Yoriko ; Jensen, Jeffrey. / Levonorgestrel-releasing intrauterine system for heavy menstrual bleeding improves hemoglobin and ferritin levels. In: Contraception. 2012 ; Vol. 86, No. 5. pp. 452-457.
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