Levonorgestrel Implants and Intracranial Hypertension

John B. Alder, F. T. Fraunfelder, Ralph Edwards, Margaret E. Weber, Howard E. Rofsky, Marc W. Deitch

Research output: Contribution to journalLetter

28 Scopus citations


To the Editor: Levonorgestrel (Norplant, Wyeth–Ayerst Laboratories, Philadelphia) is a subdermally implanted synthetic progestin that has been available in the United States since 1991. Intracranial hypertension developed in two women seen at the Oregon Health Sciences University after the insertion of this implant. We reviewed data from the national Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oreg.), the Food and Drug Administration's Spontaneous Reporting System (Rockville, Md.), and the World Health Organization's Collaborating Center for International Drug Monitoring (Uppsala, Sweden) for a possible association between levonorgestrel use and intracranial hypertension. A total of 56 cases of intracranial.

Original languageEnglish (US)
Pages (from-to)1720-1721
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Jun 22 1995

ASJC Scopus subject areas

  • Medicine(all)

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    Alder, J. B., Fraunfelder, F. T., Edwards, R., Weber, M. E., Rofsky, H. E., & Deitch, M. W. (1995). Levonorgestrel Implants and Intracranial Hypertension. New England Journal of Medicine, 332(25), 1720-1721. https://doi.org/10.1056/NEJM199506223322519